Literature DB >> 12913204

Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam.

Sandra Anne Banack1, Paul Alan Cox.   

Abstract

Beta-methylamino-L-alanine (BMAA) occurs in higher levels in museum specimens of the Guamanian flying fox than in the cycad seeds the flying foxes feed on, confirming the hypothesis that cycad neurotoxins are biomagnified within the Guam ecosystem. Consumption of a single flying fox may have resulted in an equivalent BMAA dose obtained from eating 174 to 1,014 kg of processed cycad flour. Traditional feasting on flying foxes may be related to the prevalence of neuropathologic disease in Guam.

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Year:  2003        PMID： 12913204     DOI： 10.1212/01.wnl.0000078320.18564.9f

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  63 in total

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Authors:  Catherine B Kunst
Journal:  Am J Hum Genet       Date:  2004-10-11       Impact factor: 11.025

Review 2.  The epidemiology of ALS: a conspiracy of genes, environment and time.

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3.  Creating a Simian Model of Guam ALS/PDC Which Reflects Chamorro Lifetime BMAA Exposures.

Authors:  Sandra Anne Banack; Paul Alan Cox
Journal:  Neurotox Res       Date:  2017-05-06       Impact factor: 3.911

Review 4.  A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans.

Authors:  N Chernoff; D J Hill; D L Diggs; B D Faison; B M Francis; J R Lang; M M Larue; T-T Le; K A Loftin; J N Lugo; J E Schmid; W M Winnik
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2017-06-09       Impact factor: 6.393

5.  Cyanobacterial Blooms and the Occurrence of the neurotoxin beta-N-methylamino-L-alanine (BMAA) in South Florida Aquatic Food Webs.

Authors:  Larry E Brand; John Pablo; Angela Compton; Neil Hammerschlag; Deborah C Mash
Journal:  Harmful Algae       Date:  2010-09-01       Impact factor: 4.273

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Authors:  Jörg Hanrieder; Oskar Karlsson; Eva Brittebo; Per Malmberg; Andrew G Ewing
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Review 7.  Mechanisms and Effects Posed by Neurotoxic Products of Cyanobacteria/Microbial Eukaryotes/Dinoflagellates in Algae Blooms: a Review.

Authors:  Fiona D Mello; Nady Braidy; Helder Marçal; Gilles Guillemin; Seyed Mohammad Nabavi; Brett A Neilan
Journal:  Neurotox Res       Date:  2017-08-23       Impact factor: 3.911

8.  High resolution metabolite imaging in the hippocampus following neonatal exposure to the environmental toxin BMAA using ToF-SIMS.

Authors:  Jörg Hanrieder; Lorenz Gerber; Åsa Persson Sandelius; Eva B Brittebo; Andrew G Ewing; Oskar Karlsson
Journal:  ACS Chem Neurosci       Date:  2014-05-09       Impact factor: 4.418

9.  Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.

Authors:  Amanda R Decker; Matthew S McNeill; Aaron M Lambert; Jeffrey D Overton; Yu-Chia Chen; Ramón A Lorca; Nicolas A Johnson; Susan E Brockerhoff; Durga P Mohapatra; Heather MacArthur; Pertti Panula; Mark A Masino; Loren W Runnels; Robert A Cornell
Journal:  Dev Biol       Date:  2013-11-27       Impact factor: 3.582

10.  Relative seed and fruit toxicity of the Australian cycads Macrozamia miquelii and Cycas ophiolitica: further evidence for a megafaunal seed dispersal syndrome in cycads, and its possible antiquity.

Authors:  J A Hall; G H Walter
Journal:  J Chem Ecol       Date:  2014-08-30       Impact factor: 2.626
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