Literature DB >> 12907139

Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women.

G C Burdge1, S A Wootton.   

Abstract

The purpose of this study was to determine whether adult humans can recycle carbon from alpha-linolenic acid (18:3n-3) into saturated (SFA) and monounsaturated (MUFA) fatty acids. Six men and six women consumed 700 mg [U-13C]-18:3n-3. Blood was collected over 21 days and breath over 24h. [13C]-labelled SFA and MUFA were detected in plasma phosphatidylcholine (PC) and triacylglycerol (TAG). Total labelled fatty acid incorporation into SFA and MUFA was five- and 25-fold greater in PC than TAG in men and women, respectively. [13C]-16:0 was the major labelled fatty acid in both fractions. Total [13C] incorporation into SFA and MUFA was 20% greater in men than women, and related positively (r(2) = 0.35, P<0.05) to the fractional recovery of labelled 18:3n-3 as 13CO2 on breath. These results suggest that the extent of partitioning towards beta-oxidation and carbon recycling may regulate the availability of 18:3n-3 for conversion to longer-chain fatty acids.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12907139     DOI： 10.1016/s0952-3278(03)00111-x

Source DB:  PubMed          Journal:  Prostaglandins Leukot Essent Fatty Acids        ISSN： 0952-3278            Impact factor:   4.006


  13 in total

1.  Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study.

Authors:  William S Harris; James V Pottala; Sean M Lacey; Ramachandran S Vasan; Martin G Larson; Sander J Robins
Journal:  Atherosclerosis       Date:  2012-06-07       Impact factor: 5.162

2.  A High-Fat, High-Oleic Diet, But Not a High-Fat, Saturated Diet, Reduces Hepatic α-Linolenic Acid and Eicosapentaenoic Acid Content in Mice.

Authors:  Matthew J Picklo; Eric J Murphy
Journal:  Lipids       Date:  2015-12-22       Impact factor: 1.880

3.  Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate.

Authors:  Ameer Y Taha; Mary Ann Ryan; Stephen C Cunnane
Journal:  Lipids       Date:  2006-10       Impact factor: 1.880

4.  Changes of the transcriptional and fatty acid profiles in response to n-3 fatty acids in SH-SY5Y neuroblastoma cells.

Authors:  Bénédicte Langelier; Jean-Marc Alessandri; Marie-Hélène Perruchot; Philippe Guesnet; Monique Lavialle
Journal:  Lipids       Date:  2005-07       Impact factor: 1.880

Review 5.  Elevated production of docosahexaenoic acid in females: potential molecular mechanisms.

Authors:  Alex P Kitson; Chad K Stroud; Ken D Stark
Journal:  Lipids       Date:  2010-02-12       Impact factor: 1.880

6.  Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells.

Authors:  Jean-Marc Alessandri; Audrey Extier; Bénédicte Langelier; Marie-Hélène Perruchot; Christine Heberden; Philippe Guesnet; Monique Lavialle
Journal:  Lipids       Date:  2007-10-03       Impact factor: 1.880

Review 7.  Long-chain polyunsaturated fatty acids and the preterm infant: a case study in developmentally sensitive nutrient needs in the United States.

Authors:  J Thomas Brenna
Journal:  Am J Clin Nutr       Date:  2016-01-20       Impact factor: 7.045

Review 8.  The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver disease.

Authors:  Ivan R Diamond; Anca Sterescu; Paul B Pencharz; Paul W Wales
Journal:  Pediatr Surg Int       Date:  2008-05-27       Impact factor: 1.827

9.  Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

Authors:  Rozenn N Lemaitre; Toshiko Tanaka; Weihong Tang; Ani Manichaikul; Millennia Foy; Edmond K Kabagambe; Jennifer A Nettleton; Irena B King; Lu-Chen Weng; Sayanti Bhattacharya; Stefania Bandinelli; Joshua C Bis; Stephen S Rich; David R Jacobs; Antonio Cherubini; Barbara McKnight; Shuang Liang; Xiangjun Gu; Kenneth Rice; Cathy C Laurie; Thomas Lumley; Brian L Browning; Bruce M Psaty; Yii-Der I Chen; Yechiel Friedlander; Luc Djousse; Jason H Y Wu; David S Siscovick; André G Uitterlinden; Donna K Arnett; Luigi Ferrucci; Myriam Fornage; Michael Y Tsai; Dariush Mozaffarian; Lyn M Steffen
Journal:  PLoS Genet       Date:  2011-07-28       Impact factor: 5.917

10.  Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential.

Authors:  Michio Hashimoto; Kentaro Matsuzaki; Shahdat Hossain; Tomoko Ito; Harumi Wakatsuki; Yoko Tanabe; Miho Ohno; Setsushi Kato; Kazuya Yamashita; Osamu Shido
Journal:  Foods       Date:  2021-05-19
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.