| Literature DB >> 12900291 |
Erik F J de Vries1, Ingrid J van Dillen, Aren van Waarde, Antoon T M Willemsen, Willem Vaalburg, Nanno H Mulder, Geke A P Hospers.
Abstract
In rats, the relationship between [(18)F]FHPG accumulation and HSVtk expression was studied with PET and autoradiography. [(18)F]FHPG distribution closely corresponded with HSVtk immunohistochemical staining. ROI analysis of tracer uptake 2 hours p.i. and Patlak graphical analysis were applied to quantify the PET data. For both analysis methods, the [(18)F]FHPG PET signal correlated well with the fraction of HSVtk expressing cells implanted, but showed a plateau when plotted against HSVtk protein levels. This might be due to rate limiting [(18)F]FHPG membrane transport.Entities:
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Year: 2003 PMID： 12900291 DOI： 10.1016/s0969-8051(03)00048-9
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408