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Literature DB >> 21698414

PET molecular imaging in stem cell therapy for neurological diseases.

Abstract

Human neurological diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal cord injury and multiple sclerosis are caused by loss of different types of neurons and glial cells in the brain and spinal cord. At present, there are no effective therapies against these disorders. Discovery of the therapeutic potential of stem cells offers new strategies for the treatment of neurological diseases. Direct assessment of stem cells' survival, interaction with the host and impact on neuronal functions after transplantation requires advanced in vivo imaging techniques. Positron emission tomography (PET) is a potential molecular imaging modality to evaluate the viability and function of transplanted tissue or stem cells in the nervous system. This review focuses on PET molecular imaging in stem cell therapy for neurological diseases.

Entities: Disease Species

Mesh：

Year: 2011 PMID： 21698414 DOI： 10.1007/s00259-011-1860-7

Source DB: PubMed Journal: Eur J Nucl Med Mol Imaging ISSN： 1619-7070 Impact factor: 9.236

127 in total

1. Myocardial homing of nonmobilized peripheral-blood CD34+ cells after intracoronary injection.

Authors: Didier Blocklet; Michel Toungouz; Guy Berkenboom; Micheline Lambermont; Philippe Unger; Nicolas Preumont; Eric Stoupel; Dominique Egrise; Jean-Paul Degaute; Michel Goldman; Serge Goldman
Journal: Stem Cells Date: 2005-10-13 Impact factor: 6.277

2. Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of action.

Authors: Jingxiong Wang; Sui Zhang; Brian Rabinovich; Luc Bidaut; Suren Soghomonyan; Mian M Alauddin; James A Bankson; Elizabeth Shpall; James T Willerson; Juri G Gelovani; Edward T H Yeh
Journal: Circ Res Date: 2010-05-06 Impact factor: 17.367

3. Neurons derived in vitro from ES cells express homeoproteins characteristic of motoneurons and interneurons.

Authors: Y Renoncourt; P Carroll; P Filippi; V Arce; S Alonso
Journal: Mech Dev Date: 1998-12 Impact factor: 1.882

4. Fetal and adult human CNS stem cells have similar molecular characteristics and developmental potential.

Authors: K Palm; T Salin-Nordström; M F Levesque; T Neuman
Journal: Brain Res Mol Brain Res Date: 2000-05-31

5. Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys.

Authors: Alice F Tarantal; C Chang I Lee; Cynthia A Batchelder; Jared E Christensen; Daniel Prater; Simon R Cherry
Journal: Mol Imaging Biol Date: 2012-04 Impact factor: 3.488

6. Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease.

Authors: Neelam K Venkataramana; Satish K V Kumar; Sudheer Balaraju; Radhika Chemmangattu Radhakrishnan; Abhilash Bansal; Ashish Dixit; Deepthi K Rao; Madhulita Das; Majahar Jan; Pawan Kumar Gupta; Satish M Totey
Journal: Transl Res Date: 2009-08-06 Impact factor: 7.012

7. Induced pluripotent stem cells generated without viral integration.

Authors: Matthias Stadtfeld; Masaki Nagaya; Jochen Utikal; Gordon Weir; Konrad Hochedlinger
Journal: Science Date: 2008-09-25 Impact factor: 47.728

8. Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model.

Authors: Kiryo Wakabayashi; Atsushi Nagai; Abdullah Md Sheikh; Yuri Shiota; Dashdemberel Narantuya; Tatsuzo Watanabe; Junichi Masuda; Shotai Kobayashi; Seung U Kim; Shuhei Yamaguchi
Journal: J Neurosci Res Date: 2010-04 Impact factor: 4.164

9. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.

Authors: Saravanan Karumbayaram; Bennett G Novitch; Michaela Patterson; Joy A Umbach; Laura Richter; Anne Lindgren; Anne E Conway; Amander T Clark; Steve A Goldman; Kathrin Plath; Martina Wiedau-Pazos; Harley I Kornblum; William E Lowry
Journal: Stem Cells Date: 2009-04 Impact factor: 6.277

10. Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.

Authors: P C Meltzer; A Y Liang; A L Brownell; D R Elmaleh; B K Madras
Journal: J Med Chem Date: 1993-04-02 Impact factor: 7.446

5 in total

PET molecular imaging in stem cell therapy for neurological diseases.

1. Myocardial homing of nonmobilized peripheral-blood CD34+ cells after intracoronary injection.

2. Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of action.

3. Neurons derived in vitro from ES cells express homeoproteins characteristic of motoneurons and interneurons.

4. Fetal and adult human CNS stem cells have similar molecular characteristics and developmental potential.

5. Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys.

6. Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease.

7. Induced pluripotent stem cells generated without viral integration.

8. Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model.

9. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.

10. Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.

1. MRI stem cell tracking for therapy in experimental cerebral ischemia.

Review 2. Imaging of cells and nanoparticles: implications for drug delivery to the brain.

3. Lineage mapping and characterization of the native progenitor population in cellular allograft.

Review 4. Reporter Genes for Brain Imaging Using MRI, SPECT and PET.

Review 5. Development of new technologies for stem cell research.