Literature DB >> 12898235

Expression of caveolin-1 in gastrointestinal and extraintestinal cancers.

Márk Juhász1, Jie Chen, Zsolt Tulassay, Peter Malfertheiner, Matthias P A Ebert.   

Abstract

Caveolae are uniform vesicular invaginations of the cell membrane. Caveolin-1 is responsible for the formation of caveolae and plays a key role in membrane traffic and signal transduction. The contribution of caveolin-1 to carcinogenesis has been widely investigated; however, the expression pattern of caveolin-1 is controversial both in gastrointestinal and extraintestinal cancers. Most of the results based on cancer cell line experiments suggest that caveolin-1 might act as a tumor-suppressor gene. On the contrary, several studies on the expression of caveolin-1 in tumor tissues indicate a possible tumor-promoting effect of caveolin-1. In this article we summarize the divergent results of caveolin-1 expression in gastrointestinal and extraintestinal cancer regarding possible future therapeutic implications.

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Year:  2003        PMID： 12898235     DOI： 10.1007/s00432-003-0468-0

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  41 in total

1.  Caveolae: a once-elusive structure gets some respect.

Authors:  J Marx
Journal:  Science       Date:  2001-11-30       Impact factor: 47.728

2.  Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts.

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Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

3.  Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas.

Authors:  Benoit Terris; Ekaterina Blaveri; Tatjana Crnogorac-Jurcevic; Melanie Jones; Edoardo Missiaglia; Philippe Ruszniewski; Alain Sauvanet; Nicholas R Lemoine
Journal:  Am J Pathol       Date:  2002-05       Impact factor: 4.307

4.  Reduction of caveolin and caveolae in oncogenically transformed cells.

Authors:  A J Koleske; D Baltimore; M P Lisanti
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

5.  Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage.

Authors:  Kentaro Kato; Yasuhiro Hida; Masaki Miyamoto; Hideaki Hashida; Toshiya Shinohara; Tomoo Itoh; Shunichi Okushiba; Satoshi Kondo; Hiroyuki Katoh
Journal:  Cancer       Date:  2002-02-15       Impact factor: 6.860

6.  Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases.

Authors:  S Li; J Couet; M P Lisanti
Journal:  J Biol Chem       Date:  1996-11-15       Impact factor: 5.157

7.  Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane.

Authors:  C Mineo; G L James; E J Smart; R G Anderson
Journal:  J Biol Chem       Date:  1996-05-17       Impact factor: 5.157

8.  Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells.

Authors:  S W Lee; C L Reimer; P Oh; D B Campbell; J E Schnitzer
Journal:  Oncogene       Date:  1998-03       Impact factor: 9.867

9.  Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid.

Authors:  Y Ito; H Yoshida; K Nakano; K Kobayashi; T Yokozawa; K Hirai; F Matsuzuka; N Matsuura; K Kakudo; K Kuma; A Miyauchi
Journal:  Br J Cancer       Date:  2002-03-18       Impact factor: 7.640

10.  Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma.

Authors:  M Suzuoki; M Miyamoto; K Kato; K Hiraoka; T Oshikiri; Y Nakakubo; A Fukunaga; T Shichinohe; T Shinohara; T Itoh; S Kondo; H Katoh
Journal:  Br J Cancer       Date:  2002-11-04       Impact factor: 7.640
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  5 in total

1.  Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis.

Authors:  Ozgur Mete; Isin Kilicaslan; Mine G Gulluoglu; Veli Uysal
Journal:  Virchows Arch       Date:  2005-08-17       Impact factor: 4.064

2.  Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.

Authors:  Mei-Due Yang; Ru-Yin Tsai; Chiu-Shong Liu; Chao-Hsiang Chang; Hwei-Chung Wang; Yung-An Tsou; Chung-Hsing Wang; Cheng-Chieh Lin; Song-Kun Shyue; Da-Tian Bau
Journal:  World J Gastrointest Oncol       Date:  2010-08-15

3.  Caveolin-1 promotes autoregulatory, Akt-mediated induction of cancer-promoting growth factors in prostate cancer cells.

Authors:  Likun Li; Chengzhen Ren; Guang Yang; Alexei A Goltsov; Ken-ichi Tabata; Timothy C Thompson
Journal:  Mol Cancer Res       Date:  2009-11-10       Impact factor: 5.852

4.  The potential protective role of caveolin-1 in intestinal inflammation in TNBS-induced murine colitis.

Authors:  Carolyn R Weiss; Qingdong Guan; Yanbing Ma; Gefei Qing; Charles N Bernstein; Richard J Warrington; Zhikang Peng
Journal:  PLoS One       Date:  2015-03-10       Impact factor: 3.240

5.  Bidirectional alteration of Cav-1 expression is associated with mitogenic conversion of its function in gastric tumor progression.

Authors:  Byung-Kyu Ryu; Min-Goo Lee; Nam-Hoon Kim; Kil Yeon Lee; Shin-Ju Oh; Jung-Rock Moon; Hyo Jong Kim; Sung-Gil Chi
Journal:  BMC Cancer       Date:  2017-11-15       Impact factor: 4.430
  5 in total

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