AIM: To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population. METHODS: Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing. RESULTS: There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10(-12) and 3.0 × 10(-4)) and allelic frequencies (P = 2.3 × 10(-13) and 4.0 × 10(-5)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility. CONCLUSION: This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.
AIM: To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population. METHODS: Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing. RESULTS: There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10(-12) and 3.0 × 10(-4)) and allelic frequencies (P = 2.3 × 10(-13) and 4.0 × 10(-5)) in the Cav-1G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1G14713A/T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1G14713A and T29107A genotype with smoking status on individual CRC susceptibility. CONCLUSION: This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.
Authors: E J Smart; G A Graf; M A McNiven; W C Sessa; J A Engelman; P E Scherer; T Okamoto; M P Lisanti Journal: Mol Cell Biol Date: 1999-11 Impact factor: 4.272
Authors: M H Munro; J W Blunt; E J Dumdei; S J Hickford; R E Lill; S Li; C N Battershill; A R Duckworth Journal: J Biotechnol Date: 1999-04-30 Impact factor: 3.307
Authors: E Giovannucci; G A Colditz; M J Stampfer; D Hunter; B A Rosner; W C Willett; F E Speizer Journal: J Natl Cancer Inst Date: 1994-02-02 Impact factor: 13.506
Authors: F Galbiati; J A Engelman; D Volonte; X L Zhang; C Minetti; M Li; H Hou; B Kneitz; W Edelmann; M P Lisanti Journal: J Biol Chem Date: 2001-03-19 Impact factor: 5.157