| Literature DB >> 12897771 |
Jeffrey D Wall1, Jonathan K Pritchard.
Abstract
There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.Entities:
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Year: 2003 PMID： 12897771 DOI： 10.1038/nrg1123
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242