Literature DB >> 12888555

The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited.

Fiorella Tonello1, Paolo Ascenzi, Cesare Montecucco.   

Abstract

The anthrax lethal factor (LF) is a Zn2+ endopeptidase specific for mitogen-activated protein kinase kinases (MAPKKs), which are cleaved within their N termini. Here, the proteolytic activity of LF has been investigated using novel chromogenic MAPKK-derived peptide substrates, which allowed us to determine the kinetic parameters of the reaction. LF displayed maximal proteolytic activity at the pH and temperature values of the cell cytosol, which is its site of action. LF undergoes substrate inhibition, in keeping with the non-productive binding geometry of the MAPPK-2 N terminus to LF.

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Year:  2003        PMID： 12888555     DOI： 10.1074/jbc.M306466200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  13 in total

1.  Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor.

Authors:  Arpita Agrawal; César Augusto F de Oliveira; Yuhui Cheng; Jennifer A Jacobsen; J Andrew McCammon; Seth M Cohen
Journal:  J Med Chem       Date:  2009-02-26       Impact factor: 7.446

2.  Inhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages.

Authors:  Soon-Duck Ha; Chantelle Reid; Shahab Meshkibaf; Sung Ouk Kim
Journal:  J Biol Chem       Date:  2016-02-24       Impact factor: 5.157

3.  Substrate specificity of the anthrax lethal factor.

Authors:  M Yu Zakharova; S A Dubiley; D M Chudakov; A G Gabibov; I G Shemyakin; A V Kolesnikov
Journal:  Dokl Biochem Biophys       Date:  2008 Jan-Feb       Impact factor: 0.788

4.  Cisplatin inhibition of anthrax lethal toxin.

Authors:  Mahtab Moayeri; Jason F Wiggins; Robin E Lindeman; Stephen H Leppla
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

5.  Efficient one-pot cyclization/folding of Rhesus θ-defensin-1 (RTD-1).

Authors:  Teshome L Aboye; Yilong Li; Subhabrata Majumder; Jinfeng Hao; Alexander Shekhtman; Julio A Camarero
Journal:  Bioorg Med Chem Lett       Date:  2012-03-02       Impact factor: 2.823

6.  Residue histidine 669 is essential for the catalytic activity of Bacillus anthracis lethal factor.

Authors:  Sha Cao; Aizhen Guo; Gaobing Wu; Ziduo Liu; Wei Chen; Chunfang Feng; Cheng-Cai Zhang; Huanchun Chen
Journal:  J Bacteriol       Date:  2010-09-10       Impact factor: 3.490

7.  Effects of metalloprotease anthrax lethal factor on its peptide-based inhibitor R9LF-1.

Authors:  Qingsheng Kong; Yuezhang Song; Minlei Mu; Xiaolin Han; Chuanping Si; Feng Li
Journal:  Mol Cell Biochem       Date:  2015-05-16       Impact factor: 3.396

8.  Subsite specificity of anthrax lethal factor and its implications for inhibitor development.

Authors:  Feng Li; Simon Terzyan; Jordan Tang
Journal:  Biochem Biophys Res Commun       Date:  2011-03-21       Impact factor: 3.575

9.  Small molecule inhibitors of anthrax lethal factor toxin.

Authors:  John D Williams; Atiyya R Khan; Steven C Cardinale; Michelle M Butler; Terry L Bowlin; Norton P Peet
Journal:  Bioorg Med Chem       Date:  2013-11-13       Impact factor: 3.641

10.  Substrate recognition of anthrax lethal factor examined by combinatorial and pre-steady-state kinetic approaches.

Authors:  Maria Yu Zakharova; Nikita A Kuznetsov; Svetlana A Dubiley; Arina V Kozyr; Olga S Fedorova; Dmitry M Chudakov; Dmitry G Knorre; Igor G Shemyakin; Alexander G Gabibov; Alexander V Kolesnikov
Journal:  J Biol Chem       Date:  2009-04-09       Impact factor: 5.157
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