| Literature DB >> 12885925 |
Rosa Casais1, Brian Dove, David Cavanagh, Paul Britton.
Abstract
A recombinant infectious bronchitis virus (IBV), BeauR-M41(S), was generated using our reverse genetics system (R. Casais, V. Thiel, S. G. Siddell, D. Cavanagh, and P. Britton, J. Virol. 75:12359-12369, 2001), in which the ectodomain region of the spike gene from IBV M41-CK replaced the corresponding region of the IBV Beaudette genome. BeauR-M41(S) acquired the same cell tropism phenotype as IBV M41-CK in four different cell types, demonstrating that the IBV spike glycoprotein is a determinant of cell tropism.Entities:
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Year: 2003 PMID: 12885925 PMCID: PMC167237 DOI: 10.1128/jvi.77.16.9084-9089.2003
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103