OBJECTIVE: To study the pathological characteristics of severe acute respiratory syndrome (SARS) and its relationship to clinical manifestation. METHODS: Tissue specimens from 3 autopsy cases of diagnosed SARS were studied under microscopy and the clinical data were reviewed. RESULTS: The typical pathological changes of lungs were diffuse hemorrhage on surface. A mixture features of serous, fibrinous and hemorrhagic inflammation were seen in most pulmonary alveoli with engorgement of capillary and there were microthrombosis in some capillary. Pulmonary alveoli became thick with interstitial mononuclear inflammatory infiltration, diffused alveoli damage, desquamation of pneumocytes and hyaline-membrane formation. Fibrinoid materials and erythrocytes could be found in alveolar spaces. There were thrombo-embolisms in some bronchial artery. Meanwhile, haemorrhagic necrosis was showed in lymph nodes and spleen with attenuation of lymphocytes. Other atypical pathological changes, such as hydropic degeneration, fatty degeneration, interstitial cell proliferation and some lesions observed in liver, heart, kidney, pancreas may have existed before the hospitalization. CONCLUSION: Severe damages of pulmonary and immunological system damage are responsible for clinical features of SARS and may lead to death of patients.
OBJECTIVE: To study the pathological characteristics of severe acute respiratory syndrome (SARS) and its relationship to clinical manifestation. METHODS: Tissue specimens from 3 autopsy cases of diagnosed SARS were studied under microscopy and the clinical data were reviewed. RESULTS: The typical pathological changes of lungs were diffuse hemorrhage on surface. A mixture features of serous, fibrinous and hemorrhagic inflammation were seen in most pulmonary alveoli with engorgement of capillary and there were microthrombosis in some capillary. Pulmonary alveoli became thick with interstitial mononuclear inflammatory infiltration, diffused alveoli damage, desquamation of pneumocytes and hyaline-membrane formation. Fibrinoid materials and erythrocytes could be found in alveolar spaces. There were thrombo-embolisms in some bronchial artery. Meanwhile, haemorrhagic necrosis was showed in lymph nodes and spleen with attenuation of lymphocytes. Other atypical pathological changes, such as hydropic degeneration, fatty degeneration, interstitial cell proliferation and some lesions observed in liver, heart, kidney, pancreas may have existed before the hospitalization. CONCLUSION: Severe damages of pulmonary and immunological system damage are responsible for clinical features of SARS and may lead to death of patients.
Authors: Michał Kukla; Karolina Skonieczna-Żydecka; Katarzyna Kotfis; Dominika Maciejewska; Igor Łoniewski; Luis F Lara; Monika Pazgan-Simon; Ewa Stachowska; Mariusz Kaczmarczyk; Anastasios Koulaouzidis; Wojciech Marlicz Journal: J Clin Med Date: 2020-05-11 Impact factor: 4.241
Authors: Luis Antonio Díaz; Francisco Idalsoaga; Macarena Cannistra; Roberto Candia; Daniel Cabrera; Francisco Barrera; Alejandro Soza; Rondell Graham; Arnoldo Riquelme; Marco Arrese; Michael D Leise; Juan Pablo Arab Journal: World J Gastroenterol Date: 2020-12-28 Impact factor: 5.742
Authors: Chun Shuang Guan; Zhi Bin Lv; Shuo Yan; Yan Ni Du; Hui Chen; Lian Gui Wei; Ru Ming Xie; Bu Dong Chen Journal: Acad Radiol Date: 2020-03-20 Impact factor: 3.173