Literature DB >> 12878537

Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis.

Michael W Dunne1, Chandra Khurana, Adriano Arguedas Mohs, Adib Rodriguez, Antonio Arrieta, Samuel McLinn, Judy A Krogstad, Mark Blatter, Richard Schwartz, Sergio L Vargas, Paz Emparanza, Pilar Fernandez, Willis M Gooch, Mary Aspin, John Podgore, Irmeli Roine, Jeffrey L Blumer, Garth D Ehrlich, Jean Chow.   

Abstract

Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.

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Year:  2003        PMID： 12878537      PMCID： PMC166097          DOI： 10.1128/AAC.47.8.2663-2665.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Eradication by ceftriaxone of Streptococcus pneumoniae isolates with increased resistance to penicillin in cases of acute otitis media.

Authors:  P Gehanno; L Nguyen; B Barry; M Derriennic; F Pichon; J M Goehrs; P Berche
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

2.  Acoustic reflectometry: spectral gradient analysis for improved detection of middle ear effusion in children.

Authors:  S Kimball
Journal:  Pediatr Infect Dis J       Date:  1998-06       Impact factor: 2.129

3.  A multicenter, randomized, open label comparison of azithromycin and amoxicillin/clavulanate in acute otitis media among children attending day care or school.

Authors:  C M Khurana
Journal:  Pediatr Infect Dis J       Date:  1996-09       Impact factor: 2.129

4.  A multicenter, open label trial of azithromycin for the treatment of children with acute otitis media.

Authors:  J McCarty
Journal:  Pediatr Infect Dis J       Date:  1996-09       Impact factor: 2.129

5.  A multicenter, open label trial of azithromycin vs. amoxicillin/ clavulanate for the management of acute otitis media in children.

Authors:  G Aronovitz
Journal:  Pediatr Infect Dis J       Date:  1996-09       Impact factor: 2.129

6.  Bacteriologic and clinical efficacy of high dose amoxicillin/clavulanate in children with acute otitis media.

Authors:  R Dagan; A Hoberman; C Johnson; E L Leibovitz; A Arguedas; F V Rose; B R Wynne; M R Jacobs
Journal:  Pediatr Infect Dis J       Date:  2001-09       Impact factor: 2.129

7.  Five-day twice daily cefdinir therapy for acute otitis media: microbiologic and clinical efficacy.

Authors:  S L Block; J A Hedrick; J Kratzer; M A Nemeth; K J Tack
Journal:  Pediatr Infect Dis J       Date:  2000-12       Impact factor: 2.129

8.  Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage.

Authors:  A Tait-Kamradt; T Davies; M Cronan; M R Jacobs; P C Appelbaum; J Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  2000-08       Impact factor: 5.191

9.  Detection of erythromycin-resistant determinants by PCR.

Authors:  J Sutcliffe; T Grebe; A Tait-Kamradt; L Wondrack
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

10.  Comparison of pharmacodynamics of azithromycin and erythromycin in vitro and in vivo.

Authors:  J G den Hollander; J D Knudsen; J W Mouton; K Fuursted; N Frimodt-Møller; H A Verbrugh; F Espersen
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191
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  7 in total

1.  Study design questions in treatment of children with acute otitis media.

Authors:  Alejandro Hoberman; Jack L Paradise
Journal:  Antimicrob Agents Chemother       Date:  2004-07       Impact factor: 5.191

Review 2.  Optimizing therapy with antibacterial agents: use of pharmacokinetic-pharmacodynamic principles in pediatrics.

Authors:  Christopher M Rubino; John S Bradley
Journal:  Paediatr Drugs       Date:  2007       Impact factor: 3.022

3.  Comparison of azithromycin pharmacokinetics following single oral doses of extended-release and immediate-release formulations in children with acute otitis media.

Authors:  Ping Liu; Annie F Fang; Robert R LaBadie; Penelope H Crownover; Adriano G Arguedas
Journal:  Antimicrob Agents Chemother       Date:  2011-08-22       Impact factor: 5.191

4.  High-dose azithromycin versus high-dose amoxicillin-clavulanate for treatment of children with recurrent or persistent acute otitis media.

Authors:  Antonio Arrieta; Adriano Arguedas; Pilar Fernandez; Stan L Block; Paz Emperanza; Sergio L Vargas; William A Erhardt; Pascal J de Caprariis; Constance D Rothermel
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

5.  A pilot study of single-dose azithromycin versus three-day azithromycin or single-dose ceftriaxone for uncomplicated acute otitis media in children.

Authors:  Adriano Arguedas; Cecilia Loaiza; Alexandra Perez; Alvaro Gutierrez; Marco Luis Herrera; Constance D Rothermel
Journal:  Curr Ther Res Clin Exp       Date:  2003

6.  Single-dose (30 mg/kg) azithromycin compared with 10-day amoxicillin/clavulanate for the treatment of uncomplicated acute otitis media: a double-blind, placebo-controlled, randomized clinical trial.

Authors:  Stan L Block; Antonio Arrieta; Matthew Seibel; Samuel McLinn; Stephen Eppes; Mary J Murphy
Journal:  Curr Ther Res Clin Exp       Date:  2003

7.  In vitro activities of the novel cephalosporin LB 11058 against multidrug-resistant Staphylococci and Streptococci.

Authors:  Helio S Sader; David M Johnson; Ronald N Jones
Journal:  Antimicrob Agents Chemother       Date:  2004-01       Impact factor: 5.191
  7 in total

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