| Literature DB >> 12878278 |
John R Hofstetter1, Nicholas J Grahame, Aimee R Mayeda.
Abstract
The circadian periods of high-alcohol-preferring (HAP) and low-alcohol-preferring (LAP) selected lines of mice were compared. The mice were ethanol-naive. Circadian periods were calculated from records of running-wheel activity in constant dark. The number of daily wheel revolutions and body weights of the two lines of mice were also compared. The HAP line had a shorter period of wheel running than that of the LAP lines. The HAP mice also had a tendency to run more on wheels than did LAP mice. These findings support the suggestion that genes affecting ethanol consumption in mice have pleiotropic effects on circadian period.Entities:
Mesh:
Year: 2003 PMID: 12878278 DOI: 10.1016/s0741-8329(03)00095-8
Source DB: PubMed Journal: Alcohol ISSN: 0741-8329 Impact factor: 2.405