Literature DB >> 12877182

Progress in liquid chromatography-mass spectrometry instrumentation and its impact on high-throughput screening.

W M A Niessen1.   

Abstract

In the past 10 years, liquid chromatography-mass spectrometry (LC-MS) has rapidly matured to become a very powerful and useful analytical tool that is widely applied in many areas of chemistry, pharmaceutical sciences and biochemistry. In this paper, recent instrumental developments in LC-MS-related interfacing, ionization and mass analysis are reviewed from the perspective of the application of LC-MS in high-throughput screening of combinatorial libraries and the related high-throughput quantitative bioanalysis in early drug-discovery studies, such as early adsorption, distribution, metabolism and excretion studies.

Entities:  

Mesh：

Year:  2003        PMID： 12877182     DOI： 10.1016/s0021-9673(03)00506-5

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  9 in total

1.  The distribution of ion acceptance in atmospheric pressure ion sources: spatially resolved APLI measurements.

Authors:  Matthias Lorenz; Ralf Schiewek; Klaus J Brockmann; Oliver J Schmitz; Siegmar Gäb; Thorsten Benter
Journal:  J Am Soc Mass Spectrom       Date:  2007-12-08       Impact factor: 3.109

Review 2.  Direct and indirect quantification of phosphate metabolites of nucleoside analogs in biological samples.

Authors:  Nagsen Gautam; Jawaher Abdullah Alamoudi; Sushil Kumar; Yazen Alnouti
Journal:  J Pharm Biomed Anal       Date:  2019-10-03       Impact factor: 3.935

3.  A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood.

Authors:  Xiabin Chen; Xirong Zheng; Kai Ding; Ziyuan Zhou; Chang-Guo Zhan; Fang Zheng
Journal:  J Pharm Biomed Anal       Date:  2016-11-11       Impact factor: 3.935

4.  Atmospheric Pressure Ionization Using a High Voltage Target Compared to Electrospray Ionization.

Authors:  Arnaud Lubin; Steve Bajic; Deirdre Cabooter; Patrick Augustijns; Filip Cuyckens
Journal:  J Am Soc Mass Spectrom       Date:  2016-11-28       Impact factor: 3.109

5.  Systems analysis of a maize leaf developmental gradient redefines the current C4 model and provides candidates for regulation.

Authors:  Thea R Pick; Andrea Bräutigam; Urte Schlüter; Alisandra K Denton; Christian Colmsee; Uwe Scholz; Holger Fahnenstich; Roland Pieruschka; Uwe Rascher; Uwe Sonnewald; Andreas P M Weber
Journal:  Plant Cell       Date:  2011-12-20       Impact factor: 11.277

6.  Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.

Authors:  Guodong Zhang; Alvin V Terry; Michael G Bartlett
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2007-08-17       Impact factor: 3.205

7.  Integrating Mass Spectrometry with Microphysiological Systems for Improved Neurochemical Studies.

Authors:  Emily G Tillmaand; Jonathan V Sweedler
Journal:  Microphysiol Syst       Date:  2018-06-11

8.  Integration of metabolite with transcript and enzyme activity profiling during diurnal cycles in Arabidopsis rosettes.

Authors:  Yves Gibon; Bjoern Usadel; Oliver E Blaesing; Beate Kamlage; Melanie Hoehne; Richard Trethewey; Mark Stitt
Journal:  Genome Biol       Date:  2006-08-17       Impact factor: 13.583

Review 9.  Utility of mass spectrometry for the diagnosis of the unstable coronary plaque.

Authors:  Shana S Jacob; Mohamed Hassan; Magdi H Yacoub
Journal:  Glob Cardiol Sci Pract       Date:  2015-07-04
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.