Literature DB >> 12876735

Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.

Nobutaka Fujii1, Shinya Oishi, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Hirokazu Tamamura, Akira Otaka, Shuichi Kusano, Shigemi Terakubo, Hideki Nakashima, James A Broach, John O Trent, Zi-xuan Wang, Stephen C Peiper.   

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Year:  2003        PMID： 12876735     DOI： 10.1002/anie.200351024

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  29 in total

1.  Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas.

Authors:  Keisuke Omori; Nanae Nagata; Kaori Kurata; Yoko Fukushima; Erika Sekihachi; Nobutaka Fujii; Tomoko Namba-Hamano; Yoshitsugu Takabatake; Marcus Fruttiger; Takashi Nagasawa; Akiyoshi Uemura; Takahisa Murata
Journal:  JCI Insight       Date:  2018-12-06

Review 2.  Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).

Authors:  Won-Tak Choi; Srinivas Duggineni; Yan Xu; Ziwei Huang; Jing An
Journal:  J Med Chem       Date:  2011-12-02       Impact factor: 7.446

Review 3.  Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis.

Authors:  Won-Tak Choi; Yilei Yang; Yan Xu; Jing An
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

4.  Design of RNA-targeting macrocyclic peptides.

Authors:  Matthew J Walker; Gabriele Varani
Journal:  Methods Enzymol       Date:  2019-06-13       Impact factor: 1.600

Review 5.  Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4.

Authors:  M P Rettig; G Ansstas; J F DiPersio
Journal:  Leukemia       Date:  2011-09-02       Impact factor: 11.528

6.  Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection.

Authors:  Royce A Wilkinson; Seth H Pincus; Kejing Song; Joyce B Shepard; Alan J Weaver; Mohamed E Labib; Martin Teintze
Journal:  Bioorg Med Chem Lett       Date:  2013-01-30       Impact factor: 2.823

Review 7.  Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases.

Authors:  Won-Tak Choi; Jing An
Journal:  Exp Biol Med (Maywood)       Date:  2011-05-12

8.  A benzenesulfonamide derivative as a novel PET radioligand for CXCR4.

Authors:  Yoon Hyeun Oum; Dinesh Shetty; Younghyoun Yoon; Zhongxing Liang; Ronald J Voll; Mark M Goodman; Hyunsuk Shim
Journal:  Bioorg Med Chem       Date:  2019-11-30       Impact factor: 3.641

9.  Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides.

Authors:  Maoqing Dong; Pooja Narang; Delia I Pinon; Andrew J Bordner; Laurence J Miller
Journal:  Peptides       Date:  2010-03-07       Impact factor: 3.750

10.  Exploratory studies on development of the chemokine receptor CXCR4 antagonists toward downsizing.

Authors:  Hirokazu Tamamura; Hiroshi Tsutsumi; Wataru Nomura; Nobutaka Fujii
Journal:  Perspect Medicin Chem       Date:  2008-02-10
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