Mony Benifla1, Zvi Weizman. 1. Pediatric Gastroenterology and Nutrition Unit, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Abstract
GOALS: To review the published experience with acute pancreatitis in childhood. STUDY: Computerized search of the English medical literature since 1965 using MEDLINE. RESULTS: Details of 589 patients were reviewed. Mean age was 9.2 +/- 2.4 years (range: 1 week to 21 years). Male to female ratio was 1.2. Etiologies included (n = 589): idiopathic (23%), trauma (22%), structural anomalies (15%), multisystem disease (14%), drugs and toxins (12%), viral infections (10%), hereditary (2%) and metabolic disorders (2%). Diagnosis was based most often on abnormal abdominal ultrasonography (81%) and on elevated serum amylase levels (63%). Radiograph findings were helpful in 34%. In 16% of the patients the diagnosis was based only on laparotomy. Mean hospital stay was 13.2 +/- 2.4 days and TPN was required in 28% of the patients. In 24% of the subjects a surgical intervention was indicated. Recurrence was reported in 9%, most of them with idiopathic and structural etiologies. Fatal outcome was described in 9.7% of the patients. CONCLUSIONS: Acute pancreatitis of childhood, although considered sometimes as a minor disorder, carries significant morbidity and mortality. Therefore, pediatricians should be more aware of this illness.
GOALS: To review the published experience with acute pancreatitis in childhood. STUDY: Computerized search of the English medical literature since 1965 using MEDLINE. RESULTS: Details of 589 patients were reviewed. Mean age was 9.2 +/- 2.4 years (range: 1 week to 21 years). Male to female ratio was 1.2. Etiologies included (n = 589): idiopathic (23%), trauma (22%), structural anomalies (15%), multisystem disease (14%), drugs and toxins (12%), viral infections (10%), hereditary (2%) and metabolic disorders (2%). Diagnosis was based most often on abnormal abdominal ultrasonography (81%) and on elevated serum amylase levels (63%). Radiograph findings were helpful in 34%. In 16% of the patients the diagnosis was based only on laparotomy. Mean hospital stay was 13.2 +/- 2.4 days and TPN was required in 28% of the patients. In 24% of the subjects a surgical intervention was indicated. Recurrence was reported in 9%, most of them with idiopathic and structural etiologies. Fatal outcome was described in 9.7% of the patients. CONCLUSIONS: Acute pancreatitis of childhood, although considered sometimes as a minor disorder, carries significant morbidity and mortality. Therefore, pediatricians should be more aware of this illness.
Authors: Matthew J Giefer; Mark E Lowe; Steven L Werlin; Bridget Zimmerman; Michael Wilschanski; David Troendle; Sarah Jane Schwarzenberg; John F Pohl; Joseph Palermo; Chee Y Ooi; Veronique D Morinville; Tom K Lin; Sohail Z Husain; Ryan Himes; Melvin B Heyman; Tanja Gonska; Cheryl E Gariepy; Steven D Freedman; Douglas S Fishman; Melena D Bellin; Bradley Barth; Maisam Abu-El-Haija; Aliye Uc Journal: J Pediatr Date: 2017-05-10 Impact factor: 4.406
Authors: K W Russell; D C Barnhart; J Madden; E Leeflang; W D Jackson; G P Feola; R L Meyers; E R Scaife; M D Rollins Journal: Pediatr Surg Int Date: 2012-12-29 Impact factor: 1.827