OBJECTIVES: To determine the susceptibility of southern African strains of Yersinia pestis to novel as well as conventional antimicrobial agents. MATERIALS AND METHODS: The MICs of 28 strains of Yersinia pestis from a southern African plague focus were determined by agar dilution. RESULTS: The most active agents were cefditoren and the fluoroquinolones, both conventional and novel. The in vitro activity of macrolides was poor against this member of the Enterobacteriaceae. CONCLUSION: Further investigation of the novel quinolones olamufloxacin (HSR 903) and ABT 492 in animal models of plague would seem to be justified.
OBJECTIVES: To determine the susceptibility of southern African strains of Yersinia pestis to novel as well as conventional antimicrobial agents. MATERIALS AND METHODS: The MICs of 28 strains of Yersinia pestis from a southern African plague focus were determined by agar dilution. RESULTS: The most active agents were cefditoren and the fluoroquinolones, both conventional and novel. The in vitro activity of macrolides was poor against this member of the Enterobacteriaceae. CONCLUSION: Further investigation of the novel quinolonesolamufloxacin (HSR 903) and ABT 492 in animal models of plague would seem to be justified.
Authors: K Granger; M S Rundell; M R Pingle; R Shatsky; D H Larone; L M Golightly; F Barany; E D Spitzer Journal: J Clin Microbiol Date: 2009-10-28 Impact factor: 5.948
Authors: David R Lonsway; Sandra K Urich; Henry S Heine; Sigrid K McAllister; Shailen N Banerjee; Martin E Schriefer; Jean B Patel Journal: J Clin Microbiol Date: 2011-03-16 Impact factor: 5.948
Authors: Henry S Heine; Jeremy Hershfield; Charles Marchand; Lynda Miller; Stephanie Halasohoris; Bret K Purcell; Patricia L Worsham Journal: Antimicrob Agents Chemother Date: 2015-01-12 Impact factor: 5.191