Literature DB >> 12862462

Total synthesis of apratoxin A.

Jiehao Chen1, Craig J Forsyth.   

Abstract

Apratoxin A, a cyclodepsipeptide isolated from cyanobacterial Lyngbya spp, has been synthesized. The total synthesis features stereocontrolled access to the novel polyketide and the late-stage installation of the sensitive 2,4-disubstituted thiazoline moiety using an intramolecular Staudinger reduction/aza-Wittig process.

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Year:  2003        PMID： 12862462     DOI： 10.1021/ja036050w

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  14 in total

1.  Marine natural products: a new wave of drugs?

Authors:  Rana Montaser; Hendrik Luesch
Journal:  Future Med Chem       Date:  2011-09       Impact factor: 3.808

2.  Asymmetric total synthesis and absolute stereochemistry of the neuroactive marine macrolide palmyrolide A.

Authors:  Rodolfo Tello-Aburto; Emily M Johnson; Cheyenne K Valdez; William A Maio
Journal:  Org Lett       Date:  2012-04-04       Impact factor: 6.005

3.  Evolved diversification of a modular natural product pathway: apratoxins F and G, two cytotoxic cyclic depsipeptides from a Palmyra collection of Lyngbya bouillonii.

Authors:  Kevin Tidgewell; Niclas Engene; Tara Byrum; Joseph Media; Takayuki Doi; Fred A Valeriote; William H Gerwick
Journal:  Chembiochem       Date:  2010-07-05       Impact factor: 3.164

4.  Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.

Authors:  Bo Wang; Po-Hsien Huang; Ching-Shih Chen; Craig J Forsyth
Journal:  J Org Chem       Date:  2011-01-18       Impact factor: 4.354

5.  Total Synthesis and Biological Evaluation of Apratoxin E and Its C30 Epimer: Configurational Reassignment of the Natural Product.

Authors:  Ping Wu; Weijing Cai; Qi-Yin Chen; Senhan Xu; Ruwen Yin; Yingxia Li; Wei Zhang; Hendrik Luesch
Journal:  Org Lett       Date:  2016-10-10       Impact factor: 6.005

6.  A Molecular Dynamics Simulation Study of the Association of 1,1'-Binaphthyl-2,2'-diyl hydrogenphosphate Enantiomers with a Chiral Molecular Micelle.

Authors:  Kevin F Morris; Eugene J Billiot; Fereshteh H Billiot; Ashley A Gladis; Kenny B Lipkowitz; William M Southerland; Yayin Fang
Journal:  Chem Phys       Date:  2014-08-17       Impact factor: 2.348

7.  Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A.

Authors:  Jiehao Chen; Craig J Forsyth
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-01       Impact factor: 11.205

8.  Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.

Authors:  Pilho Kim; Sunhee Kang; Helena I Boshoff; Jan Jiricek; Margaret Collins; Ramandeep Singh; Ujjini H Manjunatha; Pornwaratt Niyomrattanakit; Liang Zhang; Michael Goodwin; Thomas Dick; Thomas H Keller; Cynthia S Dowd; Clifton E Barry
Journal:  J Med Chem       Date:  2009-03-12       Impact factor: 7.446

9.  Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors.

Authors:  Weijing Cai; Qi-Yin Chen; Long H Dang; Hendrik Luesch
Journal:  ACS Med Chem Lett       Date:  2017-09-18       Impact factor: 4.345

10.  Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity.

Authors:  Qi-Yin Chen; Yanxia Liu; Hendrik Luesch
Journal:  ACS Med Chem Lett       Date:  2011-08-31       Impact factor: 4.345
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