Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Medullary thyroid carcinoma and multiple endocrine neoplasia type 2.

Literature DB >> 12858002

Medullary thyroid carcinoma and multiple endocrine neoplasia type 2.

Abstract

Medullary thyroid carcinoma (MTC) occurs as both a sporadic and an inherited disease. MTC is a consistent feature of multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial non-MEN MTC (FMTC). Plasma calcitonin is a sensitive and specific marker for the presence of MTC. Genetic testing can identify mutant gene carriers, and prophylactic total thyroidectomy should be carried out in patients with the mutant gene. The outcome of MTC is progressively worse in FMTC, MEN 2A, sporadic MTC, and MEN 2B, and MEN 2B has been found to have the worst prognosis. There is a significant genotype-phenotype correlation, which allows a more sensitive individualized approach to the timing and extent of prophylactic thyroidectomy.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12858002 DOI： 10.1385/ep:14:2:123

Source DB: PubMed Journal: Endocr Pathol ISSN： 1046-3976 Impact factor: 3.943

Keyword Cloud
References

43 in total

1. Risk and penetrance of primary hyperparathyroidism in multiple endocrine neoplasia type 2A families with mutations at codon 634 of the RET proto-oncogene. Groupe D'etude des Tumeurs à Calcitonine.

Authors: I Schuffenecker; M Virally-Monod; R Brohet; D Goldgar; B Conte-Devolx; L Leclerc; O Chabre; A Boneu; J Caron; C Houdent; E Modigliani; V Rohmer; M Schlumberger; C Eng; P J Guillausseau; G M Lenoir
Journal: J Clin Endocrinol Metab Date: 1998-02 Impact factor: 5.958

2. Partial nucleotide sequence of human calcitonin precursor mRNA identifies flanking cryptic peptides.

Authors: R K Craig; L Hall; M R Edbrooke; J Allison; I MacIntyre
Journal: Nature Date: 1982-01-28 Impact factor: 49.962

Review 3. Guidelines for diagnosis and therapy of MEN type 1 and type 2.

Authors: M L Brandi; R F Gagel; A Angeli; J P Bilezikian; P Beck-Peccoz; C Bordi; B Conte-Devolx; A Falchetti; R G Gheri; A Libroia; C J Lips; G Lombardi; M Mannelli; F Pacini; B A Ponder; F Raue; B Skogseid; G Tamburrano; R V Thakker; N W Thompson; P Tomassetti; F Tonelli; S A Wells; S J Marx
Journal: J Clin Endocrinol Metab Date: 2001-12 Impact factor: 5.958

Review 4. Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease.

Authors: C Eng; L M Mulligan
Journal: Hum Mutat Date: 1997 Impact factor: 4.878

10. Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables.

Authors: M E Dottorini; A Assi; M Sironi; G Sangalli; G Spreafico; L Colombo
Journal: Cancer Date: 1996-04-15 Impact factor: 6.860

Medullary thyroid carcinoma and multiple endocrine neoplasia type 2.

1. Risk and penetrance of primary hyperparathyroidism in multiple endocrine neoplasia type 2A families with mutations at codon 634 of the RET proto-oncogene. Groupe D'etude des Tumeurs à Calcitonine.

2. Partial nucleotide sequence of human calcitonin precursor mRNA identifies flanking cryptic peptides.

Review 3. Guidelines for diagnosis and therapy of MEN type 1 and type 2.

Review 4. Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease.

5. Current status of inherited medullary thyroid carcinoma in Japan.

6. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

7. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.

Review 8. Advances in the diagnosis and treatment of medullary thyroid carcinoma.

9. Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients.

10. Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables.