Literature DB >> 12857995

Induction and regulation of IL-12-dependent host resistance to Toxoplasma gondii.

Alan Sher1, Carmen Collazzo, Charles Scanga, Dragana Jankovic, George Yap, Julio Aliberti.   

Abstract

Resistance to the intracellular protozoan parasite Toxoplasma gondii is initiated by the induction of interleukin-12 (IL-12), which stimulates interferon (IFN)-gamma synthesis by natural killer (NK) cells and T lymphocytes. This review summarizes the work of our laboratory on the mechanisms by which the parasite triggers IL-12 synthesis, and how this response is regulated to avoid the lethal effects of excessive tissue inflammation. In addition, we present an overview of our studies investigating the mechanisms by which the IFN-gamma produced as a consequence of IL-12 stimulation controls intracellular replication of the parasite in host cells.

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Year:  2003        PMID： 12857995     DOI： 10.1385/IR:27:2-3:521

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  12 in total

1.  CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.

Authors:  J Aliberti; C Reis e Sousa; M Schito; S Hieny; T Wells; G B Huffnagle; A Sher
Journal:  Nat Immunol       Date:  2000-07       Impact factor: 25.606

2.  Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii.

Authors:  G Yap; M Pesin; A Sher
Journal:  J Immunol       Date:  2000-07-15       Impact factor: 5.422

3.  Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology.

Authors:  C Reis e Sousa; G Yap; O Schulz; N Rogers; M Schito; J Aliberti; S Hieny; A Sher
Journal:  Immunity       Date:  1999-11       Impact factor: 31.745

4.  Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.

Authors:  G A Taylor; C M Collazo; G S Yap; K Nguyen; T A Gregorio; L S Taylor; B Eagleson; L Secrest; E A Southon; S W Reid; L Tessarollo; M Bray; D W McVicar; K L Komschlies; H A Young; C A Biron; A Sher; G F Vande Woude
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

5.  Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity.

Authors:  J Aliberti; S Hieny; C Reis e Sousa; C N Serhan; A Sher
Journal:  Nat Immunol       Date:  2001-12-17       Impact factor: 25.606

6.  Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells.

Authors:  Charles A Scanga; Julio Aliberti; Dragana Jankovic; Florence Tilloy; Soumaya Bennouna; Eric Y Denkers; Ruslan Medzhitov; Alan Sher
Journal:  J Immunol       Date:  2002-06-15       Impact factor: 5.422

7.  In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas.

Authors:  C Reis e Sousa; S Hieny; T Scharton-Kersten; D Jankovic; H Charest; R N Germain; A Sher
Journal:  J Exp Med       Date:  1997-12-01       Impact factor: 14.307

8.  Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii.

Authors:  T M Scharton-Kersten; G Yap; J Magram; A Sher
Journal:  J Exp Med       Date:  1997-04-07       Impact factor: 14.307

9.  Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction.

Authors:  T Scharton-Kersten; C Contursi; A Masumi; A Sher; K Ozato
Journal:  J Exp Med       Date:  1997-11-03       Impact factor: 14.307

10.  Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-gamma- and tumor necrosis factor (TNF)-alpha-dependent host resistance to the intracellular pathogen, Toxoplasma gondii.

Authors:  G S Yap; A Sher
Journal:  J Exp Med       Date:  1999-04-05       Impact factor: 14.307
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  47 in total

1.  Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.

Authors:  Crescent L Combe; Magali M Moretto; Joseph D Schwartzman; Jason P Gigley; David J Bzik; Imtiaz A Khan
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-13       Impact factor: 11.205

2.  Transmission of Toxoplasma gondii from infected dendritic cells to natural killer cells.

Authors:  Catrine M Persson; Henrik Lambert; Polya P Vutova; Isabel Dellacasa-Lindberg; Joanna Nederby; Hideo Yagita; Hans-Gustaf Ljunggren; Alf Grandien; Antonio Barragan; Benedict J Chambers
Journal:  Infect Immun       Date:  2009-01-12       Impact factor: 3.441

Review 3.  Functional diversity and plasticity of human dendritic cell subsets.

Authors:  Tomoki Ito; Yong-Jun Liu; Norimitsu Kadowaki
Journal:  Int J Hematol       Date:  2005-04       Impact factor: 2.490

Review 4.  Unveiling the pathogen behind the vacuole.

Authors:  Peter Liehl; Vanessa Zuzarte-Luis; Maria M Mota
Journal:  Nat Rev Microbiol       Date:  2015-07-20       Impact factor: 60.633

5.  Infection with Toxoplasma gondii alters lymphotoxin expression associated with changes in splenic architecture.

Authors:  Arielle Glatman Zaretsky; Jonathan S Silver; Marie Siwicki; Amy Durham; Carl F Ware; Christopher A Hunter
Journal:  Infect Immun       Date:  2012-07-30       Impact factor: 3.441

6.  Multiple Inflammatory Cytokines Converge To Regulate CD8+ T Cell Expansion and Function during Tuberculosis.

Authors:  Matthew G Booty; Cláudio Nunes-Alves; Stephen M Carpenter; Pushpa Jayaraman; Samuel M Behar
Journal:  J Immunol       Date:  2016-01-11       Impact factor: 5.422

7.  MyD88-dependent pathway is essential for the innate immunity to Enterocytozoon bieneusi.

Authors:  Q Zhang; X Feng; W Nie; D T Golenbock; H Mayanja-Kizza; S Tzipori; H Feng
Journal:  Parasite Immunol       Date:  2011-04       Impact factor: 2.280

8.  Identification and characterization of Neospora caninum cyclophilin that elicits gamma interferon production.

Authors:  Wenbin Tuo; Raymond Fetterer; Mark Jenkins; J P Dubey
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

9.  Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of protozoan parasitic infections in vivo.

Authors:  Jennifer E Lykens; Catherine E Terrell; Erin E Zoller; Senad Divanovic; Aurelien Trompette; Christopher L Karp; Julio Aliberti; Matthew J Flick; Michael B Jordan
Journal:  J Immunol       Date:  2009-12-14       Impact factor: 5.422

10.  Effect of codon optimization and subcellular targeting on Toxoplasma gondii antigen SAG1 expression in tobacco leaves to use in subcutaneous and oral immunization in mice.

Authors:  Melina Laguía-Becher; Valentina Martín; Mauricio Kraemer; Mariana Corigliano; María L Yacono; Alejandra Goldman; Marina Clemente
Journal:  BMC Biotechnol       Date:  2010-07-15       Impact factor: 2.563
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