Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence.

Literature DB >> 12857925

Length of Epstein-Barr virus termini as a determinant of epithelial cell clonal emergence.

Cary A Moody¹, Rona S Scott, Tao Su, John W Sixbey.

Abstract

Reiterated terminal sequences of Epstein-Barr virus (EBV) DNA are numerically heterogeneous among infectious virions, providing a viral measure of clonality in infected cells. After in vitro infection, carcinoma cells bearing EBV episomes with fewer terminal repeats (TRs) proliferated faster. In single-cell clones, TR number varied inversely to the quantity of latent membrane protein 2A (LMP2A) transcripts whose unspliced precursors cross joined TRs. Thus, EBV clonality may reflect selection for a TR number that optimizes LMP2A-enhanced tumor progression, with infection occurring after epithelial cell transformation.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12857925 PMCID： PMC165260 DOI： 10.1128/jvi.77.15.8555-8561.2003

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

32 in total

1. Morphological transformation of human keratinocytes expressing the LMP gene of Epstein-Barr virus.

Authors: R Fåhraeus; L Rymo; J S Rhim; G Klein
Journal: Nature Date: 1990-05-31 Impact factor: 49.962

2. Epstein-Barr virus latent membrane protein inhibits human epithelial cell differentiation.

Authors: C W Dawson; A B Rickinson; L S Young
Journal: Nature Date: 1990-04-19 Impact factor: 49.962

3. Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction.

Authors: S Fruehling; S K Lee; R Herrold; B Frech; G Laux; E Kremmer; F A Grässer; R Longnecker
Journal: J Virol Date: 1996-09 Impact factor: 5.103

4. The Epstein-Barr virus 3.5-kilobase latent membrane protein 1 mRNA initiates from a TATA-Less promoter within the first terminal repeat.

Authors: R H Sadler; N Raab-Traub
Journal: J Virol Date: 1995-07 Impact factor: 5.103

5. An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene.

Authors: T A Gahn; B Sugden
Journal: J Virol Date: 1995-04 Impact factor: 5.103

6. An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking.

Authors: C L Miller; J H Lee; E Kieff; R Longnecker
Journal: Proc Natl Acad Sci U S A Date: 1994-01-18 Impact factor: 11.205

7. Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma.

Authors: A Neri; F Barriga; G Inghirami; D M Knowles; J Neequaye; I T Magrath; R Dalla-Favera
Journal: Blood Date: 1991-03-01 Impact factor: 22.113

8. Deletion of DNA encoding the first five transmembrane domains of Epstein-Barr virus latent membrane proteins 2A and 2B.

Authors: R Longnecker; C L Miller; B Tomkinson; X Q Miao; E Kieff
Journal: J Virol Date: 1993-08 Impact factor: 5.103

9. Epstein-Barr virus carriage by nasopharyngeal carcinoma in situ.

Authors: W M Yeung; Y S Zong; C T Chiu; K H Chan; J S Sham; D T Choy; M H Ng
Journal: Int J Cancer Date: 1993-03-12 Impact factor: 7.396

10. Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma.

Authors: R Pathmanathan; U Prasad; R Sadler; K Flynn; N Raab-Traub
Journal: N Engl J Med Date: 1995-09-14 Impact factor: 91.245

17 in total

Review 1. Integrins as triggers of Epstein-Barr virus fusion and epithelial cell infection.

Authors: Lindsey M Hutt-Fletcher; Liudmila S Chesnokova
Journal: Virulence Date: 2010 Sep-Oct Impact factor: 5.882

2. Antibodies to gp350/220 enhance the ability of Epstein-Barr virus to infect epithelial cells.

Authors: Susan M Turk; Ru Jiang; Liudmila S Chesnokova; Lindsey M Hutt-Fletcher
Journal: J Virol Date: 2006-10 Impact factor: 5.103

3. Comparative analysis of oncogenic properties and nuclear factor-kappaB activity of latent membrane protein 1 natural variants from Hodgkin's lymphoma's Reed-Sternberg cells and normal B-lymphocytes.

Authors: Nathalie Faumont; Aurélie Chanut; Alan Benard; Nadine Cogne; Georges Delsol; Jean Feuillard; Fabienne Meggetto
Journal: Haematologica Date: 2009-02-11 Impact factor: 9.941

4. Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8.

Authors: Liudmila S Chesnokova; Stephen L Nishimura; Lindsey M Hutt-Fletcher
Journal: Proc Natl Acad Sci U S A Date: 2009-11-17 Impact factor: 11.205

Review 5. The molecular march of primary and recurrent nasopharyngeal carcinoma.

Authors: Nicholas J Campion; Munira Ally; Bernhard J Jank; Jahangir Ahmed; Ghassan Alusi
Journal: Oncogene Date: 2021-01-21 Impact factor: 9.867

6. Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells.

Authors: Laura R Wasil; Leizhen Wei; Christopher Chang; Li Lan; Kathy H Y Shair
Journal: J Virol Date: 2015-05-13 Impact factor: 5.103

10. Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway.

Authors: Makoto Fukuda; Richard Longnecker
Journal: J Virol Date: 2004-02 Impact factor: 5.103