Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene.

Literature DB >> 7884916

An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene.

Abstract

Upon infection of human B lymphocytes, the 172-kbp Epstein-Barr virus genome forms a covalently closed circle via its terminal repeats. This event brings all of the promoters that control expression of the latent gene products, and the viral origin of plasmid replication, oriP, within a 20-kbp stretch of contiguous DNA. We have found that the EBNA-1-dependent transcriptional enhancer FR, located in oriP, increased the expression of a tagged viral oncogene encoding the latent membrane protein (LMP) up to 200-fold in normal Epstein-Barr virus-positive cells. The effect of FR was exerted across 10 kbp of viral DNA that spans the circularized ends of the viral genome. Enhancement of the tagged LMP gene by FR/EBNA-1 did not require the EBNA-2-responsive element.

Entities: Gene Species

Mesh：

Substances：

Year: 1995 PMID： 7884916 PMCID： PMC188944

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

23 in total

1. Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.

Authors: J I Cohen; F Wang; J Mannick; E Kieff
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205

Review 2. Immortalizing genes of Epstein-Barr virus.

Authors: T Middleton; T A Gahn; J M Martin; B Sugden
Journal: Adv Virus Res Date: 1991 Impact factor: 9.937

3. Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression.

Authors: S F Tsang; F Wang; K M Izumi; E Kieff
Journal: J Virol Date: 1991-12 Impact factor: 5.103

4. Epstein-Barr virus nuclear antigen 2 activates transcription of the terminal protein gene.

Authors: U Zimber-Strobl; K O Suentzenich; G Laux; D Eick; M Cordier; A Calender; M Billaud; G M Lenoir; G W Bornkamm
Journal: J Virol Date: 1991-01 Impact factor: 5.103

5. The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication.

Authors: T A Gahn; C L Schildkraut
Journal: Cell Date: 1989-08-11 Impact factor: 41.582

6. DNA sequence and expression of the B95-8 Epstein-Barr virus genome.

Authors: R Baer; A T Bankier; M D Biggin; P L Deininger; P J Farrell; T J Gibson; G Hatfull; G S Hudson; S C Satchwell; C Séguin
Journal: Nature Date: 1984 Jul 19-25 Impact factor: 49.962

7. Early events in Epstein-Barr virus infection of human B lymphocytes.

Authors: C Alfieri; M Birkenbach; E Kieff
Journal: Virology Date: 1991-04 Impact factor: 3.616

8. Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein.

Authors: S Fennewald; V van Santen; E Kieff
Journal: J Virol Date: 1984-08 Impact factor: 5.103

9. Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection.

Authors: M Woisetschlaeger; X W Jin; C N Yandava; L A Furmanski; J L Strominger; S H Speck
Journal: Proc Natl Acad Sci U S A Date: 1991-05-01 Impact factor: 11.205

10. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region.

Authors: D R Rawlins; G Milman; S D Hayward; G S Hayward
Journal: Cell Date: 1985-10 Impact factor: 41.582

78 in total

1. Functional analyses of the EBNA1 origin DNA binding protein of Epstein-Barr virus.

Authors: D F Ceccarelli; L Frappier
Journal: J Virol Date: 2000-06 Impact factor: 5.103

2. Infection of primary human monocytes by Epstein-Barr virus.

Authors: M Savard; C Bélanger; M Tardif; P Gourde; L Flamand; J Gosselin
Journal: J Virol Date: 2000-03 Impact factor: 5.103

3. Genetic evidence that EBNA-1 is needed for efficient, stable latent infection by Epstein-Barr virus.

Authors: M A Lee; M E Diamond; J L Yates
Journal: J Virol Date: 1999-04 Impact factor: 5.103

4. The linking regions of EBNA1 are essential for its support of replication and transcription.

Authors: D Mackey; B Sugden
Journal: Mol Cell Biol Date: 1999-05 Impact factor: 4.272

5. Modulation of histone acetyltransferase activity through interaction of epstein-barr nuclear antigen 3C with prothymosin alpha.

Authors: M A Cotter; E S Robertson
Journal: Mol Cell Biol Date: 2000-08 Impact factor: 4.272

6. Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth.

Authors: M S Kang; S C Hung; E Kieff
Journal: Proc Natl Acad Sci U S A Date: 2001-12-04 Impact factor: 11.205

7. Separation of the DNA replication, segregation, and transcriptional activation functions of Epstein-Barr nuclear antigen 1.

Authors: Hong Wu; Priya Kapoor; Lori Frappier
Journal: J Virol Date: 2002-03 Impact factor: 5.103

8. Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP.

Authors: B Wensing; A Stühler; P Jenkins; M Hollyoake; C E Karstegl; P J Farrell
Journal: J Virol Date: 2001-07 Impact factor: 5.103

9. Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin.

Authors: Jie Lu; Masanao Murakami; Subhash C Verma; Qiliang Cai; Sabyasachi Haldar; Rajeev Kaul; Mariusz A Wasik; Jaap Middeldorp; Erle S Robertson
Journal: Virology Date: 2010-11-19 Impact factor: 3.616

10. Contributions of CTCF and DNA methyltransferases DNMT1 and DNMT3B to Epstein-Barr virus restricted latency.

Authors: David J Hughes; Elessa M Marendy; Carol A Dickerson; Kristen D Yetming; Clare E Sample; Jeffery T Sample
Journal: J Virol Date: 2011-11-09 Impact factor: 5.103