AIM: To study the significance of polymorphism of MHC class I chain-related gene A (MICA) gene in patients with cholelithiasis. METHODS: Subjects included 170 unrelated adults (83 males) with cholelithiasis and 245 randomly selected unrelated adults (130 males) as controls. DNA was extracted from peripheral leukocytes and analyzed for polymorphism of 5 alleles (A4, A5, A5.1, A6 and A9) of the MICA gene. RESULTS: There was no significant difference in phenotype, allele, and genotype frequencies of any of the 5 alleles between cholelithiasis patients and controls. CONCLUSION: This study demonstrates that MICA alleles studied bear no relation to cholelithiasis.
AIM: To study the significance of polymorphism of MHC class I chain-related gene A (MICA) gene in patients with cholelithiasis. METHODS: Subjects included 170 unrelated adults (83 males) with cholelithiasis and 245 randomly selected unrelated adults (130 males) as controls. DNA was extracted from peripheral leukocytes and analyzed for polymorphism of 5 alleles (A4, A5, A5.1, A6 and A9) of the MICA gene. RESULTS: There was no significant difference in phenotype, allele, and genotype frequencies of any of the 5 alleles between cholelithiasispatients and controls. CONCLUSION: This study demonstrates that MICA alleles studied bear no relation to cholelithiasis.
Authors: M Ota; Y Katsuyama; N Mizuki; H Ando; K Furihata; S Ono; P Pivetti-Pezzi; K F Tabbara; G D Palimeris; B Nikbin; F Davatchi; H Chams; Z Geng; S Bahram; H Inoko Journal: Tissue Antigens Date: 1997-05
Authors: T Kobayashi; K Tamemoto; K Nakanishi; N Kato; M Okubo; H Kajio; T Sugimoto; T Murase; K Kosaka Journal: Diabetes Care Date: 1993-05 Impact factor: 19.112