| Literature DB >> 12852972 |
Jagabandhu Das1, Robert V Moquin, James Lin, Chunjian Liu, Arthur M Doweyko, Henry F DeFex, Qiong Fang, Suhong Pang, Sidney Pitt, Ding Ren Shen, Gary L Schieven, Joel C Barrish, John Wityak.
Abstract
A series of structurally novel benzothiazole based small molecule inhibitors of p56(lck) was prepared to elucidate their structure-activity relationships (SAR), selectivity and cell activity in the T-cell proliferation assay. BMS-350751 (2) and BMS-358233 (3) are identified as potent Lck inhibitors with excellent cellular activities against T-cell proliferation.Entities:
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Year: 2003 PMID： 12852972 DOI： 10.1016/s0960-894x(03)00511-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823