Literature DB >> 12852941

Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system.

R John Scott1, Lu-Yun Lian, S Hanna Muharram, Alan Cockayne, Stewart J Wood, Barrie W Bycroft, Paul Williams, Weng C Chan.   

Abstract

The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is activated in response to a secreted autoinducer peptide (AIP). By exploiting the unique chemical architecture of the naturally occurring AIP-1, several potent inhibitors of staphylococcal TCSTS were designed and synthesized using either a linear or branched solid-phase approach. These inhibitors are competitive binders and contain the crucial 16-membered side-chain-to-tail thiolactone peptide pharmacophore.

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Year:  2003        PMID： 12852941     DOI： 10.1016/s0960-894x(03)00497-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

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Authors:  Steve Atkinson; Paul Williams
Journal:  J R Soc Interface       Date:  2009-08-12       Impact factor: 4.118

2.  Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing.

Authors:  Christopher P Gordon; Shondra D Olson; Jessica L Lister; Jeffrey S Kavanaugh; Alexander R Horswill
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3.  Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

Authors:  Joseph K Vasquez; Yftah Tal-Gan; Gabriel Cornilescu; Kimberly A Tyler; Helen E Blackwell
Journal:  Chembiochem       Date:  2017-01-20       Impact factor: 3.164

Review 4.  Antibiofilm agents: A new perspective for antimicrobial strategy.

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Journal:  J Microbiol       Date:  2017-09-28       Impact factor: 3.422

5.  Conformational Switch to a β-Turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency.

Authors:  Joseph K Vasquez; Korbin H J West; Tian Yang; Thomas J Polaske; Gabriel Cornilescu; Marco Tonelli; Helen E Blackwell
Journal:  J Am Chem Soc       Date:  2020-01-02       Impact factor: 15.419

6.  Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation.

Authors:  Tian Yang; Yftah Tal-Gan; Alexandra E Paharik; Alexander R Horswill; Helen E Blackwell
Journal:  ACS Chem Biol       Date:  2016-05-18       Impact factor: 5.100

7.  Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniae.

Authors:  Yifang Yang; Jingjun Lin; Anthony Harrington; Gabriel Cornilescu; Gee W Lau; Yftah Tal-Gan
Journal:  Proc Natl Acad Sci U S A       Date:  2020-01-08       Impact factor: 11.205

Review 8.  Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections.

Authors:  Burhan A Khan; Anthony J Yeh; Gordon Y C Cheung; Michael Otto
Journal:  Expert Opin Investig Drugs       Date:  2015-02-23       Impact factor: 6.206

9.  Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus.

Authors:  Yftah Tal-Gan; Monika Ivancic; Gabriel Cornilescu; Claudia C Cornilescu; Helen E Blackwell
Journal:  J Am Chem Soc       Date:  2013-11-25       Impact factor: 15.419

Review 10.  Cyclic Peptides that Govern Signal Transduction Pathways: From Prokaryotes to Multi-Cellular Organisms.

Authors:  Ryan W Mull; Anthony Harrington; Lucia A Sanchez; Yftah Tal-Gan
Journal:  Curr Top Med Chem       Date:  2018       Impact factor: 3.295
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