Literature DB >> 29773060

Cyclic Peptides that Govern Signal Transduction Pathways: From Prokaryotes to Multi-Cellular Organisms.

Ryan W Mull1, Anthony Harrington1, Lucia A Sanchez1, Yftah Tal-Gan1.   

Abstract

Cyclic peptide scaffolds are key components of signal transduction pathways in both prokaryotic and eukaryotic organisms since they act as chemical messengers that activate or inhibit specific cognate receptors. In prokaryotic organisms these peptides are utilized in non-essential pathways, such as quorum sensing, that are responsible for virulence and pathogenicity. In the more evolved eukaryotic systems, cyclic peptide hormones play a key role in the regulation of the overall function of multicellular organisms, mainly through the endocrine system. This review will highlight several prokaryote and eukaryote systems that use cyclic peptides as their primary signals and the potential associated with utilizing these scaffolds for the discovery of novel therapeutics for a wide range of diseases and illnesses. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Cyclic peptides; autoinducers; eukaryotes; hormones; prokaryotes; quorum sensing; signal transduction.

Mesh：

Substances：

Year:  2018        PMID： 29773060      PMCID： PMC6050129          DOI： 10.2174/1568026618666180518090705

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  185 in total

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Review 3.  Quorum sensing: cell-to-cell communication in bacteria.

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4.  High genetic variability of the agr locus in Staphylococcus species.

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6.  LuxS/autoinducer-2 quorum sensing molecule regulates transcriptional virulence gene expression in Clostridium difficile.

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Journal:  Biochem Biophys Res Commun       Date:  2005-09-30       Impact factor: 3.575

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Journal:  Curr Diabetes Rev       Date:  2013-01-01

8.  Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC.

Authors:  G J Lyon; P Mayville; T W Muir; R P Novick
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Review 4.  Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria.

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Review 6.  Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria.

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7.  Rational Design of Potent Activators and Inhibitors of the Enterococcus faecalis Fsr Quorum Sensing Circuit.

Authors:  Dominic N McBrayer; Crissey D Cameron; Brooke K Gantman; Yftah Tal-Gan
Journal:  ACS Chem Biol       Date:  2018-09-07       Impact factor: 5.100

Review 8.  Elucidating Solution Structures of Cyclic Peptides Using Molecular Dynamics Simulations.

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Journal:  Chem Rev       Date:  2021-01-11       Impact factor: 60.622

9.  Biological Evaluation of Native Streptococcal Competence Stimulating Peptides Reveal Potential Crosstalk Between Streptococcus mitis and Streptococcus pneumoniae and a New Scaffold for the Development of S. pneumoniae Quorum Sensing Modulators.

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Journal:  Nat Commun       Date:  2021-03-25       Impact factor: 14.919
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