Literature DB >> 12850209

Unnatural amino acid mutagenesis in mapping ion channel function.

Darren L Beene1, Dennis A Dougherty, Henry A Lester.   

Abstract

Unnatural amino acid mutagenesis makes possible the site-specific incorporation of synthetic amino acids, enabling detailed structure-function studies as well as the incorporation of biophysical probes. This method has been adapted for use with heterologous expression in Xenopus oocytes, allowing experiments on ion channels.

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Year:  2003        PMID： 12850209     DOI： 10.1016/s0959-4388(03)00068-0

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


  34 in total

1.  Photochemical tools to study dynamic biological processes.

Authors:  Alexandre Specht; Frédéric Bolze; Ziad Omran; Jean-François Nicoud; Maurice Goeldner
Journal:  HFSP J       Date:  2009-05-22

Review 2.  Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology.

Authors:  Stephan A Pless; Robin Y Kim; Christopher A Ahern; Harley T Kurata
Journal:  J Physiol       Date:  2015-03-13       Impact factor: 5.182

3.  In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression.

Authors:  Erik A Rodriguez; Henry A Lester; Dennis A Dougherty
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-25       Impact factor: 11.205

Review 4.  Tethering chemistry and K+ channels.

Authors:  Trevor J Morin; William R Kobertz
Journal:  J Biol Chem       Date:  2008-06-09       Impact factor: 5.157

5.  Genetically Encoding Unnatural Amino Acids in Neurons In Vitro and in the Embryonic Mouse Brain for Optical Control of Neuronal Proteins.

Authors:  Ji-Yong Kang; Daichi Kawaguchi; Lei Wang
Journal:  Methods Mol Biol       Date:  2018

6.  A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.

Authors:  Stephan A Pless; Ariele P Hanek; Kerry L Price; Joseph W Lynch; Henry A Lester; Dennis A Dougherty; Sarah C R Lummis
Journal:  Mol Pharmacol       Date:  2011-01-25       Impact factor: 4.436

7.  Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit.

Authors:  Angela P Blum; Kristin Rule Gleitsman; Henry A Lester; Dennis A Dougherty
Journal:  J Biol Chem       Date:  2011-07-13       Impact factor: 5.157

8.  A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.

Authors:  Roger S Zhang; Jordan D Wright; Stephan A Pless; John-Jose Nunez; Robin Y Kim; Jenny B W Li; Runying Yang; Christopher A Ahern; Harley T Kurata
Journal:  J Biol Chem       Date:  2015-05-01       Impact factor: 5.157

Review 9.  High throughput electrophysiology with Xenopus oocytes.

Authors:  Roger L Papke; Cathy Smith-Maxwell
Journal:  Comb Chem High Throughput Screen       Date:  2009-01       Impact factor: 1.339

10.  The Xenopus oocyte: a single-cell model for studying Ca2+ signaling.

Authors:  Yaping Lin-Moshier; Jonathan S Marchant
Journal:  Cold Spring Harb Protoc       Date:  2013-03-01
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