Literature DB >> 12849183

The therapeutic potential of cannabis.

David Baker1, Gareth Pryce, Gavin Giovannoni, Alan J Thompson.   

Abstract

Research of the cannabinoid system has many similarities with that of the opioid system. In both instances, studies into drug-producing plants led to the discovery of an endogenous control system with a central role in neurobiology. Few compounds have had as much positive press from patients as those of the cannabinoid system. While these claims are investigated in disorders such as multiple sclerosis spasticity and pain, basic research is discovering interesting members of this family of compounds that have previously unknown qualities, the most notable of which is the capacity for neuroprotection. Large randomised clinical trials of the better known compounds are in progress. Even if the results of these studies are not as positive as many expect them to be, that we are only just beginning to appreciate the huge therapeutic potential of this family of compounds is clear.

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Year:  2003        PMID: 12849183     DOI: 10.1016/s1474-4422(03)00381-8

Source DB:  PubMed          Journal:  Lancet Neurol        ISSN: 1474-4422            Impact factor:   44.182


  56 in total

1.  Does marijuana have a future in pharmacopoeia?

Authors:  Giovanni Frazzetto
Journal:  EMBO Rep       Date:  2003-07       Impact factor: 8.807

Review 2.  Blurred boundaries: the therapeutics and politics of medical marijuana.

Authors:  J Michael Bostwick
Journal:  Mayo Clin Proc       Date:  2012-02       Impact factor: 7.616

Review 3.  Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility.

Authors:  Stefan S du Plessis; Ashok Agarwal; Arun Syriac
Journal:  J Assist Reprod Genet       Date:  2015-08-16       Impact factor: 3.412

4.  In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?

Authors:  B B Yao; S Mukherjee; Y Fan; T R Garrison; A V Daza; G K Grayson; B A Hooker; M J Dart; J P Sullivan; M D Meyer
Journal:  Br J Pharmacol       Date:  2006-08-07       Impact factor: 8.739

5.  CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents.

Authors:  Catherine Lombard; Mitzi Nagarkatti; Prakash Nagarkatti
Journal:  Clin Immunol       Date:  2006-12-20       Impact factor: 3.969

6.  Continuous infusion of the cannabinoid WIN 55,212-2 to the site of a peripheral nerve injury reduces mechanical and cold hypersensitivity.

Authors:  I J Lever; T M Pheby; A S C Rice
Journal:  Br J Pharmacol       Date:  2007-03-20       Impact factor: 8.739

7.  Crystallization of Delta1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa.

Authors:  Yoshinari Shoyama; Ayako Takeuchi; Futoshi Taura; Taro Tamada; Motoyasu Adachi; Ryota Kuroki; Yukihiro Shoyama; Satoshi Morimoto
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2005-07-30

Review 8.  Cannabinoids for the treatment of dementia.

Authors:  Sarada Krishnan; Ruth Cairns; Robert Howard
Journal:  Cochrane Database Syst Rev       Date:  2009-04-15

9.  Cannabinoid hyperemesis syndrome: clinical diagnosis of an underrecognised manifestation of chronic cannabis abuse.

Authors:  Siva P Sontineni; Sanjay Chaudhary; Vijaya Sontineni; Stephen J Lanspa
Journal:  World J Gastroenterol       Date:  2009-03-14       Impact factor: 5.742

Review 10.  Role of endocannabinoid system in mental diseases.

Authors:  Jorge Manzanares; Leyre Urigüen; Gabriel Rubio; Tomás Palomo
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

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