| Literature DB >> 12848295 |
M Lagarde1, C Calzada, E Véricel.
Abstract
Decrease of platelet glutathione peroxidase activity results in increased life span of lipid hydroperoxides, especially the 12-lipoxygenase product of arachidonic acid, 12-HpETE. Phospholipase A2 activity is subsequently enhanced with the release of arachidonic acid, which results in higher thromboxane formation and platelet function. Docosahexaenoic acid may either potentiate platelet lipid peroxidation or lower it when used at high or low concentrations, respectively. In the case of slowing down lipid peroxidation, docosahexaenoic acid was specifically incorporated in plasmalogen ethanolamine phospholipids. This could have a relevant pathophysiologic role in atherothrombosis.Entities:
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Year: 2003 PMID： 12848295 DOI： 10.1007/s11745-003-1085-x
Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880