David L Pauls1. 1. Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 10th Floor, Charlestown, MA 02129, USA. pauls@psych.mgh.harvard.edu
Abstract
OBJECTIVES: To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic. METHODS: The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized. RESULTS AND CONCLUSIONS: There is considerable data that suggests that: (1). genetic factors play an important role in the manifestation of GTS; (2). several genes are important with some possibly having major effect; and (3). several regions of the genome have been identified as potential locations of these susceptibility genes.
OBJECTIVES: To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic. METHODS: The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized. RESULTS AND CONCLUSIONS: There is considerable data that suggests that: (1). genetic factors play an important role in the manifestation of GTS; (2). several genes are important with some possibly having major effect; and (3). several regions of the genome have been identified as potential locations of these susceptibility genes.
Authors: P Paschou; Y Feng; A J Pakstis; W C Speed; M M DeMille; J R Kidd; B Jaghori; R Kurlan; D L Pauls; P Sandor; C L Barr; K K Kidd Journal: Am J Hum Genet Date: 2004-08-09 Impact factor: 11.025
Authors: Jacquelyn Crane; Jesen Fagerness; Lisa Osiecki; Boyd Gunnell; S Evelyn Stewart; David L Pauls; Jeremiah M Scharf Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-11-02 Impact factor: 3.568
Authors: Bradley S Peterson; HuiMahn A Choi; Xuejun Hao; Jose A Amat; Hongtu Zhu; Ronald Whiteman; Jun Liu; Dongrong Xu; Ravi Bansal Journal: Arch Gen Psychiatry Date: 2007-11