Literature DB >> 12842030

Neurodegeneration: how does parkin prevent Parkinson's disease?

Mark R Cookson1.   

Abstract

Mutations in parkin cause Parkinson's disease due to the loss of the ubiquitin-protein ligase activity of Parkin protein. Recent data suggest we may be beginning to understand the nature of the proteins that are targeted by Parkin and how these cause neuronal damage.

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Year:  2003        PMID： 12842030     DOI： 10.1016/s0960-9822(03)00446-9

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  6 in total

1.  Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.

Authors:  Cheng Wang; Ruifeng Lu; Xuezhi Ouyang; Michelle W L Ho; William Chia; Fengwei Yu; Kah-Leong Lim
Journal:  J Neurosci       Date:  2007-08-08       Impact factor: 6.167

Review 2.  Role of ubiquitin protein ligases in the pathogenesis of polyglutamine diseases.

Authors:  Priyanka Dikshit; Nihar Ranjan Jana
Journal:  Neurochem Res       Date:  2007-09-01       Impact factor: 3.996

3.  Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability.

Authors:  Alexandra Beilina; Marcel Van Der Brug; Rili Ahmad; Sashi Kesavapany; David W Miller; Gregory A Petsko; Mark R Cookson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-11       Impact factor: 11.205

Review 4.  Genetics of parkin-linked disease.

Authors:  Andrew B West; Nigel T Maidment
Journal:  Hum Genet       Date:  2004-01-15       Impact factor: 4.132

5.  Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.

Authors:  Xiao-Hong Lu; Sheila M Fleming; Bernhard Meurers; Larry C Ackerson; Farzad Mortazavi; Victor Lo; Daniela Hernandez; David Sulzer; George R Jackson; Nigel T Maidment; Marie-Francoise Chesselet; X William Yang
Journal:  J Neurosci       Date:  2009-02-18       Impact factor: 6.167

6.  Mutations in PRKN and SNCA Genes Important for the Progress of Parkinson's Disease.

Authors:  Anna Oczkowska; Wojciech Kozubski; Margarita Lianeri; Jolanta Dorszewska
Journal:  Curr Genomics       Date:  2013-12       Impact factor: 2.236
  6 in total

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