Literature DB >> 12840853

[Implication of mutation of hepatitis C virus 1b interferon sensitivity determining region(NS5A aa 2209-2248) response to interferon alpha therapy in patients with chronic hepatitis C].

Z Tang1, J Köck, D Moradpour, D Yang, L Hao, H Blum.   

Abstract

Hepatitis C virus (HCV) isolates from 12 patients with chronic hepatitis C underwent the sequence analysis. Among the 12 patients, 9 obtained a complete response (CR), 2 partial response (PR) and 1 non--response (NR) after the treatment with IFN-alpha. The results showed that only single amino acid (aa) substitution in iIFN sensitivity determining region (ISDR) (aa 2213 and aa 2218) in 6 cases with CR was observed, while 3 cases of CR and all PR and NR cases had no aa mutation of ISDR. It is suggested that the ISDR in HCV NS5A was yet not identified by our patients.

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Year:  1999        PMID： 12840853     DOI： 10.1007/BF02886890

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  14 in total

Review 1.  Current state of interferon therapy for chronic hepatitis C.

Authors:  S Iino; K Hino; K Yasuda
Journal:  Intervirology       Date:  1994       Impact factor: 1.763

2.  Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.

Authors:  G Squadrito; F Leone; M Sartori; B Nalpas; P Berthelot; G Raimondo; S Pol; C Bréchot
Journal:  Gastroenterology       Date:  1997-08       Impact factor: 22.682

Review 3.  Therapy of hepatitis C.

Authors:  M W Fried; J H Hoofnagle
Journal:  Semin Liver Dis       Date:  1995-02       Impact factor: 6.115

Review 4.  Variants of hepatitis B, C and D viruses: molecular biology and clinical significance.

Authors:  H E Blum
Journal:  Digestion       Date:  1995       Impact factor: 3.216

5.  Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5' non-coding region.

Authors:  F Davidson; P Simmonds; J C Ferguson; L M Jarvis; B C Dow; E A Follett; C R Seed; T Krusius; C Lin; G A Medgyesi
Journal:  J Gen Virol       Date:  1995-05       Impact factor: 3.891

6.  HCV-associated liver cancer without cirrhosis.

Authors:  M S De Mitri; K Poussin; P Baccarini; P Pontisso; A D'Errico; N Simon; W Grigioni; A Alberti; M Beaugrand; E Pisi
Journal:  Lancet       Date:  1995-02-18       Impact factor: 79.321

Review 7.  Natural history of hepatitis C.

Authors:  K Kiyosawa; E Tanaka; T Sodeyama; S Furuta
Journal:  Intervirology       Date:  1994       Impact factor: 1.763

8.  Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients.

Authors:  H Khorsi; S Castelain; A Wyseur; J Izopet; V Canva; A Rombout; D Capron; J P Capron; F Lunel; L Stuyver; G Duverlie
Journal:  J Hepatol       Date:  1997-07       Impact factor: 25.083

9.  Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein.

Authors:  M J Gale; M J Korth; N M Tang; S L Tan; D A Hopkins; T E Dever; S J Polyak; D R Gretch; M G Katze
Journal:  Virology       Date:  1997-04-14       Impact factor: 3.616

10.  Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.

Authors:  N Enomoto; I Sakuma; Y Asahina; M Kurosaki; T Murakami; C Yamamoto; N Izumi; F Marumo; C Sato
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808
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