Literature DB >> 12837845

Cholesterol: from heart attacks to Alzheimer's disease.

Robert L Raffai1, Karl H Weisgraber.   

Abstract

The accumulation and aggregation of the amyloid-beta peptide (Abeta) in the brain are important contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of Abeta is a potentially important treatment strategy. Recent work on the metabolism of Abeta has identified several cellular proteins and proteases that collectively promote or prevent the generation of Abeta. In addition, accumulating in vitro and in vivo evidence suggests a role for cholesterol in modulating the cellular processing of Abeta with the potential to affect AD.

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Year:  2003        PMID： 12837845     DOI： 10.1194/jlr.R300007-JLR200

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  21 in total

1.  Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4.

Authors:  Chiharu Mizuguchi; Mami Hata; Padmaja Dhanasekaran; Margaret Nickel; Michael C Phillips; Sissel Lund-Katz; Hiroyuki Saito
Journal:  Biochemistry       Date:  2012-07-03       Impact factor: 3.162

2.  Association of CYP46 intron 2 polymorphism in Finnish Alzheimer's disease samples and a global scale summary.

Authors:  S Helisalmi; S Vepsäläinen; A M Koivisto; A Mannermaa; S Iivonen; M Hiltunen; V Kiviniemi; H Soininen
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-03       Impact factor: 10.154

Review 3.  The effects of cholesterol on learning and memory.

Authors:  Bernard G Schreurs
Journal:  Neurosci Biobehav Rev       Date:  2010-05-12       Impact factor: 8.989

Review 4.  Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap?

Authors:  Gurdeep Marwarha; Othman Ghribi
Journal:  Exp Gerontol       Date:  2014-09-28       Impact factor: 4.032

5.  Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices.

Authors:  Celine Ullrich; Michael Pirchl; Christian Humpel
Journal:  Pharmacology       Date:  2010-06-23       Impact factor: 2.547

Review 6.  Acyl-coenzyme A:cholesterol acyltransferases.

Authors:  Ta-Yuan Chang; Bo-Liang Li; Catherine C Y Chang; Yasuomi Urano
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-01-13       Impact factor: 4.310

7.  Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoforms.

Authors:  Takaaki Sakamoto; Masafumi Tanaka; Charulatha Vedhachalam; Margaret Nickel; David Nguyen; Padmaja Dhanasekaran; Michael C Phillips; Sissel Lund-Katz; Hiroyuki Saito
Journal:  Biochemistry       Date:  2008-01-18       Impact factor: 3.162

8.  Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits.

Authors:  Celine Ullrich; Michael Pirchl; Christian Humpel
Journal:  Mol Cell Neurosci       Date:  2010-08-06       Impact factor: 4.314

9.  Structural variation in human apolipoprotein E3 and E4: secondary structure, tertiary structure, and size distribution.

Authors:  Chi-Yuan Chou; Yi-Ling Lin; Yu-Chyi Huang; Sheh-Yi Sheu; Ta-Hsien Lin; Huey-Jen Tsay; Gu-Gang Chang; Ming-Shi Shiao
Journal:  Biophys J       Date:  2004-10-08       Impact factor: 4.033

10.  Prenatal Ethanol Exposure Up-Regulates the Cholesterol Transporters ATP-Binding Cassette A1 and G1 and Reduces Cholesterol Levels in the Developing Rat Brain.

Authors:  Chunyan Zhou; Jing Chen; Xiaolu Zhang; Lucio G Costa; Marina Guizzetti
Journal:  Alcohol Alcohol       Date:  2014-07-31       Impact factor: 2.826
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