Literature DB >> 19141679

Acyl-coenzyme A:cholesterol acyltransferases.

Ta-Yuan Chang1, Bo-Liang Li, Catherine C Y Chang, Yasuomi Urano.   

Abstract

The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.

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Year:  2009        PMID： 19141679      PMCID： PMC2711667          DOI： 10.1152/ajpendo.90926.2008

Source DB:  PubMed          Journal:  Am J Physiol Endocrinol Metab        ISSN： 0193-1849            Impact factor:   4.310


  100 in total

1.  Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT.

Authors:  Yukio Fujiwara; Naoko Kiyota; Masaharu Hori; Sayaka Matsushita; Yoko Iijima; Koh Aoki; Daisuke Shibata; Motohiro Takeya; Tsuyoshi Ikeda; Toshihiro Nohara; Ryoji Nagai
Journal:  Arterioscler Thromb Vasc Biol       Date:  2007-09-13       Impact factor: 8.311

2.  Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A.

Authors:  Akash Das; Matthew A Davis; Hiroshi Tomoda; Satoshi Omura; Lawrence L Rudel
Journal:  J Biol Chem       Date:  2008-02-19       Impact factor: 5.157

3.  Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.

Authors:  J Mark Brown; Thomas A Bell; Heather M Alger; Janet K Sawyer; Thomas L Smith; Kathryn Kelley; Ramesh Shah; Martha D Wilson; Matthew A Davis; Richard G Lee; Mark J Graham; Rosanne M Crooke; Lawrence L Rudel
Journal:  J Biol Chem       Date:  2008-02-14       Impact factor: 5.157

4.  Ghrelin octanoylation mediated by an orphan lipid transferase.

Authors:  Jesus A Gutierrez; Patricia J Solenberg; Douglas R Perkins; Jill A Willency; Michael D Knierman; Zhaoyan Jin; Derrick R Witcher; Shuang Luo; Jude E Onyia; John E Hale
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-28       Impact factor: 11.205

5.  Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes.

Authors:  Taichi Ohshiro; Lawrence L Rudel; Satoshi Omura; Hiroshi Tomoda
Journal:  J Antibiot (Tokyo)       Date:  2007-01       Impact factor: 2.649

6.  Statin therapy alone and in combination with an acyl-CoA:cholesterol O-acyltransferase inhibitor on experimental atherosclerosis.

Authors:  Stephen G Worthley; Gérard Helft; Roberto Corti; Matthew I Worthley; Derek P Chew; Zahi A Fayad; Azfar G Zaman; John T Fallon; Valentin Fuster; Juan J Badimon
Journal:  Pathophysiol Haemost Thromb       Date:  2008-03-06

7.  Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages.

Authors:  Daisuke Matsuda; Satoshi Ohte; Taichi Ohshiro; Wei Jiang; Lawrence Rudel; Bin Hong; Shuyi Si; Hiroshi Tomoda
Journal:  Biol Pharm Bull       Date:  2008-06       Impact factor: 2.233

8.  Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1.

Authors:  Zhan-Yun Guo; Catherine C Y Chang; Ta-Yuan Chang
Journal:  Biochemistry       Date:  2007-08-11       Impact factor: 3.162

Review 9.  ACAT as a drug target for Alzheimer's disease.

Authors:  Henri J Huttunen; Dora M Kovacs
Journal:  Neurodegener Dis       Date:  2008-03-06       Impact factor: 2.977

10.  Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

Authors:  Jing Yang; Michael S Brown; Guosheng Liang; Nick V Grishin; Joseph L Goldstein
Journal:  Cell       Date:  2008-02-08       Impact factor: 41.582
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  146 in total

1.  A lipoprotein source of cholesteryl esters is essential for proliferation of CEM-CCRF lymphoblastic cell line.

Authors:  Sabrina Uda; Simonetta Accossu; Stefano Spolitu; Maria Collu; Fabrizio Angius; Francesca Sanna; Sebastiano Banni; Claudia Vacca; Elisabetta Murru; Claudia Mulas; Giacomo Diaz; Barbara Batetta
Journal:  Tumour Biol       Date:  2011-12-10

2.  Avasimibe encapsulated in human serum albumin blocks cholesterol esterification for selective cancer treatment.

Authors:  Steve Seung-Young Lee; Junjie Li; Jien Nee Tai; Timothy L Ratliff; Kinam Park; Ji-Xin Cheng
Journal:  ACS Nano       Date:  2015-02-16       Impact factor: 15.881

3.  Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.

Authors:  Yohei Shibuya; Zhaoyang Niu; Elena Y Bryleva; Brent T Harris; Stephanie R Murphy; Alireza Kheirollah; Zachary D Bowen; Catherine C Y Chang; Ta-Yuan Chang
Journal:  Neurobiol Aging       Date:  2015-04-07       Impact factor: 4.673

4.  Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids.

Authors:  Alessandro Venosa; Ley Cody Smith; Alexa Murray; Tanvi Banota; Andrew J Gow; Jeffrey D Laskin; Debra L Laskin
Journal:  Toxicol Sci       Date:  2019-12-01       Impact factor: 4.849

Review 5.  Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis.

Authors:  Yifeng Wang; Wen-Xing Ding; Tiangang Li
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2018-04-10       Impact factor: 4.698

6.  Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome.

Authors:  Xiaochen Liu; Gloria Michelle Ducasa; Shamroop Kumar Mallela; Jin-Ju Kim; Judith Molina; Alla Mitrofanova; Sydney Symone Wilbon; Mengyuan Ge; Antonio Fontanella; Christopher Pedigo; Javier Varona Santos; Robert G Nelson; Yelena Drexler; Gabriel Contreras; Hassan Al-Ali; Sandra Merscher; Alessia Fornoni
Journal:  Kidney Int       Date:  2020-07-30       Impact factor: 10.612

7.  Nanodisc scaffold peptide (NSPr) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs.

Authors:  Bryan Neumann; Kevin Chao; Catherine C Y Chang; Ta-Yuan Chang
Journal:  Arch Biochem Biophys       Date:  2020-07-28       Impact factor: 4.013

8.  Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase.

Authors:  Martin S Taylor; Travis R Ruch; Po-Yuan Hsiao; Yousang Hwang; Pingfeng Zhang; Lixin Dai; Cheng Ran Lisa Huang; Christopher E Berndsen; Min-Sik Kim; Akhilesh Pandey; Cynthia Wolberger; Ronen Marmorstein; Carolyn Machamer; Jef D Boeke; Philip A Cole
Journal:  J Biol Chem       Date:  2013-09-17       Impact factor: 5.157

9.  Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/β-catenin Pathway.

Authors:  Hyeon Jeong Lee; Jie Li; Renee E Vickman; Junjie Li; Rui Liu; Abigail C Durkes; Bennett D Elzey; Shuhua Yue; Xiaoqi Liu; Timothy L Ratliff; Ji-Xin Cheng
Journal:  Mol Cancer Res       Date:  2018-03-15       Impact factor: 5.852

10.  TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation.

Authors:  Lei Lei; Ying Xiong; Jia Chen; Jin-Bo Yang; Yi Wang; Xin-Ying Yang; Catherine C Y Chang; Bao-Liang Song; Ta-Yuan Chang; Bo-Liang Li
Journal:  J Lipid Res       Date:  2009-02-02       Impact factor: 5.922
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