Literature DB >> 12835579

Veno-occlusive disease in a fetus caused by pyrrolizidine alkaloids of food origin.

R Rasenack1, C Müller, M Kleinschmidt, J Rasenack, H Wiedenfeld.   

Abstract

We report the occurrence of veno-occlusive disease in a preterm neonate who was symptomatic with hepatomegaly and ascites and was delivered by caesarean section for threatening fetal asphyxia and died shortly afterwards. Post mortem examination revealed veno-occlusive disease typical for pyrrolizidine alkaloid poisoning. The content of pyrrolizidine alkaloids in the liver could be confirmed. Analysis of a herbal mixture which was used for cooking in the family revealed high amounts of the respective alkaloids clarifying the source of the poison and the causal relationship. Copyright 2003 S. Karger AG, Basel

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Year:  2003        PMID： 12835579     DOI： 10.1159/000070799

Source DB:  PubMed          Journal:  Fetal Diagn Ther        ISSN： 1015-3837            Impact factor:   2.587


  7 in total

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Authors:  Richard Kleiman; E Danielle Rentz; Eyasu Teshale; Nicola Thompson; Helen Schurz-Rogers
Journal:  J Med Toxicol       Date:  2008-09

Review 2.  Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids.

Authors:  Yisheng He; Lin Zhu; Jiang Ma; Ge Lin
Journal:  Arch Toxicol       Date:  2021-05-18       Impact factor: 5.153

Review 3.  A systematic review of the reporting of adverse events associated with medical herb use among children.

Authors:  Paula Gardiner; Denise Adams; Amanda C Filippelli; Hafsa Nasser; Robert Saper; Laura White; Sunita Vohra
Journal:  Glob Adv Health Med       Date:  2013-03

Review 4.  Dehydropyrrolizidine Alkaloid Toxicity, Cytotoxicity, and Carcinogenicity.

Authors:  Bryan L Stegelmeier; Steven M Colegate; Ammon W Brown
Journal:  Toxins (Basel)       Date:  2016-11-29       Impact factor: 4.546

Review 5.  A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Tea and Herbal Infusions.

Authors:  Michael Habs; Karin Binder; Stefan Krauss; Karolina Müller; Brigitte Ernst; Luzia Valentini; Michael Koller
Journal:  Nutrients       Date:  2017-07-07       Impact factor: 5.717

Review 6.  A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Herbal Medicinal Products Containing St. John's Wort Extracts (SJW).

Authors:  Michael Habs; Karin Binder; Stefan Krauss; Karolina Müller; Brigitte Ernst; Luzia Valentini; Michael Koller
Journal:  Nutrients       Date:  2018-06-22       Impact factor: 5.717

Review 7.  Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity.

Authors:  Jiang Ma; Qingsu Xia; Peter P Fu; Ge Lin
Journal:  J Food Drug Anal       Date:  2018-06-14       Impact factor: 6.157
  7 in total

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