Literature DB >> 34003343

Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids.

Yisheng He1, Lin Zhu1, Jiang Ma1, Ge Lin2.   

Abstract

Pyrrolizidine alkaloids (PAs) and PA N-oxides are common phytotoxins produced by over 6000 plant species. Humans are frequently exposed to PAs via ingestion of PA-containing herbal products or PA-contaminated foods. PAs require metabolic activation to form pyrrole-protein adducts and pyrrole-DNA adducts which lead to cytotoxicity and genotoxicity. Individual PAs differ in their metabolic activation patterns, which may cause significant difference in toxic potency of different PAs. This review discusses the current knowledge and recent advances of metabolic pathways of different PAs, especially the metabolic activation and metabolism-mediated cytotoxicity and genotoxicity, and the risk evaluation methods of PA exposure. In addition, this review provides perspectives of precision toxicity assessment strategies and biomarker development for the risk control and translational investigations of human intoxication by PAs.

Entities:  

Keywords:  Cytotoxicity; Genotoxicity; Metabolic activation; Metabolism-mediated hepatotoxicity; Pyrrolizidine alkaloids

Mesh：

Substances：

Year:  2021        PMID： 34003343     DOI： 10.1007/s00204-021-03060-w

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  178 in total

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  4 in total

1.  Fasting augments pyrrolizidine alkaloid-induced hepatotoxicity.

Authors:  Jiang Ma; Chunyuan Zhang; Yisheng He; Xinmeng Chen; Ge Lin
Journal:  Arch Toxicol       Date:  2021-11-18       Impact factor: 5.153

2.  Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid.

Authors:  Lin Zhu; Junyi Xue; Yisheng He; Qingsu Xia; Peter P Fu; Ge Lin
Journal:  Toxins (Basel)       Date:  2022-05-28       Impact factor: 5.075

3.  Pyrrolizidine Alkaloid-Induced Hepatotoxicity Associated with the Formation of Reactive Metabolite-Derived Pyrrole-Protein Adducts.

Authors:  Jiang Ma; Mi Li; Na Li; Wood Yee Chan; Ge Lin
Journal:  Toxins (Basel)       Date:  2021-10-13       Impact factor: 4.546

4.  Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation.

Authors:  Zhangting Wang; Jiang Ma; Sheng Yao; Yisheng He; Kai-Kei Miu; Qingsu Xia; Peter P Fu; Yang Ye; Ge Lin
Journal:  Front Pharmacol       Date:  2022-03-16       Impact factor: 5.810
  4 in total

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