Literature DB >> 12834296

Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.

Atsushi Sano1, Jun Yamakoshi, Shoichi Tokutake, Koichiro Tobe, Yoshiro Kubota, Mamoru Kikuchi.   

Abstract

To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were administered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and beta-glucuronidase, blood samples were analyzed by HPLC coupled with mass-spectrometry (LC/MS). Procyanidin B1 [epicatechin-(4beta-->8)-catechin] was detected in human serum 2 h after intake. Its concentration was 10.6 +/- 2.5 nmol/l.

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Year:  2003        PMID: 12834296     DOI: 10.1271/bbb.67.1140

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN: 0916-8451            Impact factor:   2.043


  40 in total

1.  Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells.

Authors:  Sangeeta Shrotriya; Gagan Deep; Mallikarjuna Gu; Manjinder Kaur; Anil K Jain; Swetha Inturi; Rajesh Agarwal; Chapla Agarwal
Journal:  Carcinogenesis       Date:  2012-01-19       Impact factor: 4.944

2.  Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization.

Authors:  Dongjie Wang; Lap Ho; Jeremiah Faith; Kenjiro Ono; Elsa M Janle; Pamela J Lachcik; Bruce R Cooper; Amber H Jannasch; Bruce R D'Arcy; Barbara A Williams; Mario G Ferruzzi; Samara Levine; Wei Zhao; Lauren Dubner; Giulio M Pasinetti
Journal:  Mol Nutr Food Res       Date:  2015-04-27       Impact factor: 5.914

3.  The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers.

Authors:  Andrew K L Goey; Irma Meijerman; Jos H Beijnen; Jan H M Schellens
Journal:  Eur J Clin Pharmacol       Date:  2013-07-24       Impact factor: 2.953

4.  Grape extract improves antioxidant status and physical performance in elite male athletes.

Authors:  Sophie Lafay; Caroline Jan; Karine Nardon; Benoit Lemaire; Alvin Ibarra; Marc Roller; Marc Houvenaeghel; Christine Juhel; Louis Cara
Journal:  J Sports Sci Med       Date:  2009-09-01       Impact factor: 2.988

Review 5.  Multi-targeted prevention and therapy of cancer by proanthocyanidins.

Authors:  Vijayalakshmi Nandakumar; Tripti Singh; Santosh K Katiyar
Journal:  Cancer Lett       Date:  2008-05-23       Impact factor: 8.679

Review 6.  Flavanols and anthocyanins in cardiovascular health: a review of current evidence.

Authors:  Sonia de Pascual-Teresa; Diego A Moreno; Cristina García-Viguera
Journal:  Int J Mol Sci       Date:  2010-04-13       Impact factor: 5.923

7.  Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease.

Authors:  Mario G Ferruzzi; Jessica K Lobo; Elsa M Janle; Bruce Cooper; James E Simon; Qing-Li Wu; Cara Welch; Lap Ho; Connie Weaver; Giulio M Pasinetti
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

8.  Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract.

Authors:  Jeevan K Prasain; Ning Peng; Yanying Dai; Ray Moore; Alireza Arabshahi; Landon Wilson; Stephen Barnes; J Michael Wyss; Helen Kim; Ray L Watts
Journal:  Phytomedicine       Date:  2008-12-17       Impact factor: 5.340

Review 9.  Dietary proanthocyanidins inhibit UV radiation-induced skin tumor development through functional activation of the immune system.

Authors:  Santosh K Katiyar
Journal:  Mol Nutr Food Res       Date:  2016-04-13       Impact factor: 5.914

10.  Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol.

Authors:  Kyoichi Osada; Takashi Suzuki; Yuki Kawakami; Mineo Senda; Atsushi Kasai; Manabu Sami; Yutaka Ohta; Tomomasa Kanda; Mitsuo Ikeda
Journal:  Lipids       Date:  2006-02       Impact factor: 1.880

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