Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Gene therapy in the treatment of intestinal inflammation.

Literature DB >> 12827411

Gene therapy in the treatment of intestinal inflammation.

Catherine van Montfrans¹, Anje A te Velde, Sander J H van Deventer, Maria Sol Rodriguez Pena.

Abstract

BACKGROUND: Local expression of anti-inflammatory or immunoregulatory genes may offer an alternative treatment of gastrointestinal inflammation. DISCUSSION: We review the basic requirements for gene therapy, the possible routes of delivery, and the different strategies for specific targeting focusing on gastrointestinal inflammation.

Entities: Disease

Mesh：

Year: 2003 PMID： 12827411 DOI： 10.1007/s00384-003-0501-4

Source DB: PubMed Journal: Int J Colorectal Dis ISSN： 0179-1958 Impact factor: 2.571

72 in total

1. Targeting antigen in mature dendritic cells for simultaneous stimulation of CD4+ and CD8+ T cells.

Authors: C Bonini; S P Lee; S R Riddell; P D Greenberg
Journal: J Immunol Date: 2001-04-15 Impact factor: 5.422

2. Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector.

Authors: V Dardalhon; S Jaleco; C Rebouissou; C Ferrand; N Skander; L Swainson; P Tiberghien; H Spits; N Noraz; N Taylor
Journal: Blood Date: 2000-08-01 Impact factor: 22.113

3. Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes.

Authors: D A Sweetser; E H Birkenmeier; P C Hoppe; D W McKeel; J I Gordon
Journal: Genes Dev Date: 1988-10 Impact factor: 11.361

Review 4. Physiologic mechanisms of postischemic tissue injury.

Authors: D N Granger; R J Korthuis
Journal: Annu Rev Physiol Date: 1995 Impact factor: 19.318

Review 5. Immune regulation by CD40 and its ligand GP39.

Authors: T M Foy; A Aruffo; J Bajorath; J E Buhlmann; R J Noelle
Journal: Annu Rev Immunol Date: 1996 Impact factor: 28.527

Review 6. Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation.

Authors: D M Rennick; M M Fort
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2000-06 Impact factor: 4.052

Gene therapy in the treatment of intestinal inflammation.

1. Targeting antigen in mature dendritic cells for simultaneous stimulation of CD4+ and CD8+ T cells.

2. Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector.

3. Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes.

Review 4. Physiologic mechanisms of postischemic tissue injury.

Review 5. Immune regulation by CD40 and its ligand GP39.

Review 6. Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation.

7. Production and concentration of pseudotyped HIV-1-based gene transfer vectors.

8. Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model.

9. HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia.

10. On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunity.

1. The effect of vascular endothelial growth factor overexpression in experimental necrotizing enterocolitis.

2. Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors.

3. Rotavirus-like particles: a novel nanocarrier for the gut.