Literature DB >> 1282570

Discovery of a potent substance P antagonist: recognition of the key molecular determinant.

M C Desai1, S L Lefkowitz, P F Thadeio, K P Longo, R M Snider.   

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Year:  1992        PMID: 1282570     DOI: 10.1021/jm00104a018

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


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  17 in total

1.  Endothelium-dependent relaxation followed by contraction mediated by NK(1) receptors in precontracted rabbit intrapulmonary arteries.

Authors:  H Shirahase; M Kanda; K Kurahashi; S Nakamura
Journal:  Br J Pharmacol       Date:  2000-03       Impact factor: 8.739

2.  Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist.

Authors:  Steven Ballet; Debby Feytens; Koen Buysse; Nga N Chung; Carole Lemieux; Suneeta Tumati; Attila Keresztes; Joost Van Duppen; Josephine Lai; Eva Varga; Frank Porreca; Peter W Schiller; Jozef Vanden Broeck; Dirk Tourwé
Journal:  J Med Chem       Date:  2011-03-17       Impact factor: 7.446

3.  A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes.

Authors:  Anders Poulsen; Tommy Liljefors; Klaus Gundertofte; Berith Bjørnholm
Journal:  J Comput Aided Mol Des       Date:  2002-04       Impact factor: 3.686

4.  Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2.

Authors:  H Shirahase; M Kanda; K Kurahashi; S Nakamura; H Usui; Y Shimizu
Journal:  Br J Pharmacol       Date:  1995-08       Impact factor: 8.739

5.  The conformation of substance P in lipid environments.

Authors:  D A Keire; T G Fletcher
Journal:  Biophys J       Date:  1996-04       Impact factor: 4.033

6.  The influence of the trigeminal ganglion on carotid blood flow in anaesthetized guinea-pigs.

Authors:  D T Beattie; H E Connor
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

7.  The orientation and dynamics of substance P in lipid environments.

Authors:  D A Keire; M Kobayashi
Journal:  Protein Sci       Date:  1998-11       Impact factor: 6.725

8.  Synthesis of (+)-CP-99,994 via Pd(0)-catalyzed asymmetric allylic and homoallylic C-H Diamination of terminal olefin.

Authors:  Renzhong Fu; Baoguo Zhao; Yian Shi
Journal:  J Org Chem       Date:  2009-10-02       Impact factor: 4.354

9.  Sulfinimine-derived 2,3-diamino esters in the asymmetric synthesis of piperidine (2S,3S)-(+)-CP-99,994.

Authors:  Franklin A Davis; Yanfeng Zhang; Danyang Li
Journal:  Tetrahedron Lett       Date:  2007-10-29       Impact factor: 2.415

10.  Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.

Authors:  J Longmore; Z Razzaque; D Shaw; R G Hill
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

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