Literature DB >> 12821484

Nonsense mutations in the lsa-like gene in Enterococcus faecalis isolates susceptible to lincosamides and Streptogramins A.

Julia Dina1, Brigitte Malbruny, Roland Leclercq.   

Abstract

The lsa gene confers intrinsic resistance to lincosamides and streptogramins A in Enterococcus faecalis, probably by active efflux. The lsa-like genes of two clinical isolates of E. faecalis susceptible to lincosamides and dalfopristin contained mutations that produced premature termination codons. Revertant mutants were obtained by selection on agar plates containing clindamycin.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12821484      PMCID： PMC161836          DOI： 10.1128/AAC.47.7.2307-2309.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family.

Authors:  J I Ross; E A Eady; J H Cove; W J Cunliffe; S Baumberg; J C Wootton
Journal:  Mol Microbiol       Date:  1990-07       Impact factor: 3.501

2.  Identification of Enterococcus species isolated from human infections by a conventional test scheme.

Authors:  R R Facklam; M D Collins
Journal:  J Clin Microbiol       Date:  1989-04       Impact factor: 5.948

3.  Sequence of a staphylococcal plasmid gene, vga, encoding a putative ATP-binding protein involved in resistance to virginiamycin A-like antibiotics.

Authors:  J Allignet; V Loncle; N el Sohl
Journal:  Gene       Date:  1992-08-01       Impact factor: 3.688

Review 4.  The Escherichia coli ATP-binding cassette (ABC) proteins.

Authors:  K J Linton; C F Higgins
Journal:  Mol Microbiol       Date:  1998-04       Impact factor: 3.501

5.  Effects of genes encoding resistance to streptogramins A and B on the activity of quinupristin-dalfopristin against Enterococcus faecium.

Authors:  B Bozdogan; R Leclercq
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

6.  In vitro activity of 19 antimicrobial agents against enterococci from healthy subjects and hospitalized patients and use of an ace gene probe from Enterococcus faecalis for species identification.

Authors:  R W Duh; K V Singh; K Malathum; B E Murray
Journal:  Microb Drug Resist       Date:  2001       Impact factor: 3.431

7.  An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin.

Authors:  Kavindra V Singh; George M Weinstock; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

8.  Minimal functional system required for expression of erythromycin resistance by msrA in Staphylococcus aureus RN4220.

Authors:  J I Ross; E A Eady; J H Cove; S Baumberg
Journal:  Gene       Date:  1996-12-12       Impact factor: 3.688

9.  Disruption of an Enterococcus faecium species-specific gene, a homologue of acquired macrolide resistance genes of staphylococci, is associated with an increase in macrolide susceptibility.

Authors:  K V Singh; K Malathum; B E Murray
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

10.  Comparative in-vitro activity of erythromycin, vancomycin and pristinamycin.

Authors:  J P Maskell; A M Sefton; J Yong; S J Chi; J D Williams
Journal:  Infection       Date:  1988       Impact factor: 3.553
View more
  14 in total

1.  Differences in the Enterococcus faecalis lsa locus that influence susceptibility to quinupristin-dalfopristin and clindamycin.

Authors:  Kavindra V Singh; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

2.  Activity of a new oral streptogramin, XRP2868, against gram-positive cocci harboring various mechanisms of resistance to streptogramins.

Authors:  Michel Dupuis; Roland Leclercq
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

Review 3.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

Review 4.  Xenobiotic efflux in bacteria and fungi: a genomics update.

Authors:  Ravi D Barabote; Jose Thekkiniath; Richard E Strauss; Govindsamy Vediyappan; Joe A Fralick; Michael J San Francisco
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  2011

5.  A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamides.

Authors:  G Novotna; J Janata
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

6.  Genetic basis for in vitro and in vivo resistance to lincosamides, streptogramins A, and pleuromutilins (LSAP phenotype) in Enterococcus faecium.

Authors:  Christophe Isnard; Brigitte Malbruny; Roland Leclercq; Vincent Cattoir
Journal:  Antimicrob Agents Chemother       Date:  2013-07-08       Impact factor: 5.191

7.  Antimicrobial resistance of Enterococcus spp. isolates from raw beef and meat products.

Authors:  A Sustacková; E Nápravníková; J Schlegelová
Journal:  Folia Microbiol (Praha)       Date:  2004       Impact factor: 2.099

8.  A trilocus sequence typing scheme for hospital epidemiology and subspecies differentiation of an important nosocomial pathogen, Enterococcus faecalis.

Authors:  Shahreen A Chowdhury; Cesar A Arias; Sreedhar R Nallapareddy; Jinnethe Reyes; Rob J L Willems; Barbara E Murray
Journal:  J Clin Microbiol       Date:  2009-07-01       Impact factor: 5.948

9.  Genus-Wide Assessment of Antibiotic Resistance in Lactobacillus spp.

Authors:  Ilenia Campedelli; Harsh Mathur; Elisa Salvetti; Siobhán Clarke; Mary C Rea; Sandra Torriani; R Paul Ross; Colin Hill; Paul W O'Toole
Journal:  Appl Environ Microbiol       Date:  2018-12-13       Impact factor: 4.792

10.  Lower prevalence of antibiotic-resistant Enterococci on U.S. conventional poultry farms that transitioned to organic practices.

Authors:  Amy R Sapkota; R Michael Hulet; Guangyu Zhang; Patrick McDermott; Erinna L Kinney; Kellogg J Schwab; Sam W Joseph
Journal:  Environ Health Perspect       Date:  2011-08-10       Impact factor: 9.031
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.