Literature DB >> 12821482

Inhibitory effect of NO-releasing ciprofloxacin (NCX 976) on Mycobacterium tuberculosis survival.

R Ciccone1, F Mariani, A Cavone, T Persichini, G Venturini, E Ongini, V Colizzi, M Colasanti.   

Abstract

Here, we report the antimycobacterial activity of NCX 976, a new molecule obtained adding a NO moiety to the fluoroquinolone ciprofloxacin, on Mycobacterium tuberculosis H37Rv strain, both in a cell-free model and in infected human macrophages. Unlike unaltered ciprofloxacin, NCX976 displayed a marked activity also at low-nanomolar concentrations.

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Year:  2003        PMID： 12821482      PMCID： PMC161842          DOI： 10.1128/AAC.47.7.2299-2302.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Authors:  P del Soldato; R Sorrentino; A Pinto
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2.  A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis.

Authors:  M Couture; S R Yeh; B A Wittenberg; J B Wittenberg; Y Ouellet; D L Rousseau; M Guertin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

3.  Comparative antimicrobial activities of the newly synthesized quinolone WQ-3034, levofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex.

Authors:  H Tomioka; K Sato; H Kajitani; T Akaki; S Shishido
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

4.  Mycobacteriocidal action of exogenous nitric oxide.

Authors:  R Long; B Light; J A Talbot
Journal:  Antimicrob Agents Chemother       Date:  1999-02       Impact factor: 5.191

Review 5.  Nitric oxide and parasitic disease.

Authors:  I A Clark; K A Rockett
Journal:  Adv Parasitol       Date:  1996       Impact factor: 3.870

Review 6.  S-nitrosylation of viral proteins: molecular bases for antiviral effect of nitric oxide.

Authors:  M Colasanti; T Persichini; G Venturini; P Ascenzi
Journal:  IUBMB Life       Date:  1999-07       Impact factor: 3.885

Review 7.  The clinical use of fluoroquinolones for the treatment of mycobacterial diseases.

Authors:  G J Alangaden; S A Lerner
Journal:  Clin Infect Dis       Date:  1997-11       Impact factor: 9.079

Review 8.  Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria.

Authors:  M U Shiloh; C F Nathan
Journal:  Curr Opin Microbiol       Date:  2000-02       Impact factor: 7.934

Review 9.  Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis.

Authors:  Thomas C Zahrt; Vojo Deretic
Journal:  Antioxid Redox Signal       Date:  2002-02       Impact factor: 8.401

10.  Regulation of hmp gene transcription in Mycobacterium tuberculosis: effects of oxygen limitation and nitrosative and oxidative stress.

Authors:  Y Hu; P D Butcher; J A Mangan; M A Rajandream; A R Coates
Journal:  J Bacteriol       Date:  1999-06       Impact factor: 3.490
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  5 in total

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2.  Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosis.

Authors:  Graham S Timmins; Sharon Master; Frank Rusnak; Vojo Deretic
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

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Authors:  Nargis Khan; Aurobind Vidyarthi; Shifa Javed; Javed N Agrewala
Journal:  Front Microbiol       Date:  2016-03-14       Impact factor: 5.640

Review 4.  The role of airway epithelial cells in response to mycobacteria infection.

Authors:  Yong Li; Yujiong Wang; Xiaoming Liu
Journal:  Clin Dev Immunol       Date:  2012-04-18

Review 5.  Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis.

Authors:  Susanta Pahari; Gurpreet Kaur; Shikha Negi; Mohammad Aqdas; Deepjyoti K Das; Hilal Bashir; Sanpreet Singh; Mukta Nagare; Junaid Khan; Javed N Agrewala
Journal:  Front Immunol       Date:  2018-02-09       Impact factor: 7.561
  5 in total

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