Literature DB >> 12819116

Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis.

Martin S Pavelka1, Bing Chen, Cynthia L Kelley, Frank M Collins, William R Jacobs.   

Abstract

The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.

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Year:  2003        PMID： 12819116      PMCID： PMC161997          DOI： 10.1128/IAI.71.7.4190-4192.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  10 in total

1.  Boosting vaccine for tuberculosis.

Authors:  J V Brooks; A A Frank; M A Keen; J T Bellisle; I M Orme
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

2.  Comparison of the construction of unmarked deletion mutations in Mycobacterium smegmatis, Mycobacterium bovis bacillus Calmette-Guérin, and Mycobacterium tuberculosis H37Rv by allelic exchange.

Authors:  M S Pavelka; W R Jacobs
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

3.  Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine.

Authors:  M Jackson; S W Phalen; M Lagranderie; D Ensergueix; P Chavarot; G Marchal; D N McMurray; B Gicquel; C Guilhot
Journal:  Infect Immun       Date:  1999-06       Impact factor: 3.441

4.  Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis.

Authors:  M K Hondalus; S Bardarov; R Russell; J Chan; W R Jacobs; B R Bloom
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441

5.  Global tuberculosis incidence and mortality during 1990-2000.

Authors:  P J Dolin; M C Raviglione; A Kochi
Journal:  Bull World Health Organ       Date:  1994       Impact factor: 9.408

6.  New vaccines for the prevention of tuberculosis.

Authors:  C Fordham von Reyn; Jenni M Vuola
Journal:  Clin Infect Dis       Date:  2002-07-24       Impact factor: 9.079

7.  Characterization of auxotrophic mutants of Mycobacterium tuberculosis and their potential as vaccine candidates.

Authors:  D A Smith; T Parish; N G Stoker; G J Bancroft
Journal:  Infect Immun       Date:  2001-02       Impact factor: 3.441

8.  Molecular analysis of the aroA gene of Pasteurella multocida and vaccine potential of a constructed aroA mutant.

Authors:  P Homchampa; R A Strugnell; B Adler
Journal:  Mol Microbiol       Date:  1992-12       Impact factor: 3.501

9.  Auxotrophic vaccines for tuberculosis.

Authors:  I Guleria; R Teitelbaum; R A McAdam; G Kalpana; W R Jacobs; B R Bloom
Journal:  Nat Med       Date:  1996-03       Impact factor: 53.440

Review 10.  Antituberculous immunity: new solutions to an old problem.

Authors:  F M Collins
Journal:  Rev Infect Dis       Date:  1991 Sep-Oct
  10 in total
  37 in total

1.  Surface expression of MPT64 as a fusion with the PE domain of PE_PGRS33 enhances Mycobacterium bovis BCG protective activity against Mycobacterium tuberculosis in mice.

Authors:  Michela Sali; Gabriele Di Sante; Alessandro Cascioferro; Antonella Zumbo; Chiara Nicolò; Valentina Donà; Stefano Rocca; Annabella Procoli; Matteo Morandi; Francesco Ria; Giorgio Palù; Giovanni Fadda; Riccardo Manganelli; Giovanni Delogu
Journal:  Infect Immun       Date:  2010-10-04       Impact factor: 3.441

2.  Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.

Authors:  Vasan K Sambandamurthy; Steven C Derrick; Kripa V Jalapathy; Bing Chen; Robert G Russell; Sheldon L Morris; William R Jacobs
Journal:  Infect Immun       Date:  2005-02       Impact factor: 3.441

3.  Immunological responses and protective immunity against tuberculosis conferred by vaccination of Balb/C mice with the attenuated Mycobacterium tuberculosis (phoP) SO2 strain.

Authors:  D Aguilar; E Infante; C Martin; E Gormley; B Gicquel; R Hernandez Pando
Journal:  Clin Exp Immunol       Date:  2007-02       Impact factor: 4.330

4.  Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection.

Authors:  Najmeeyah Brown; Muazzam Jacobs; Shreemanta K Parida; Tania Botha; Aldina Santos; Lizette Fick; Brigitte Gicquel; Mary Jackson; Valerie Quesniaux; Bernhard Ryffel
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

Review 5.  Mycobacterium tuberculosis in the Face of Host-Imposed Nutrient Limitation.

Authors:  Michael Berney; Linda Berney-Meyer
Journal:  Microbiol Spectr       Date:  2017-06

6.  Withdrawn

Authors: 
Journal:  Infect Disord Drug Targets       Date:  2012-11-16

7.  Brucella abortus Depends on l-Serine Biosynthesis for Intracellular Proliferation.

Authors:  Virginia Révora; María Inés Marchesini; Diego J Comerci
Journal:  Infect Immun       Date:  2020-01-22       Impact factor: 3.441

8.  Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening.

Authors:  Garth L Abrahams; Anuradha Kumar; Suzana Savvi; Alvin W Hung; Shijun Wen; Chris Abell; Clifton E Barry; David R Sherman; Helena I M Boshoff; Valerie Mizrahi
Journal:  Chem Biol       Date:  2012-07-27

9.  Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis.

Authors:  Joseph Hinchey; Bo Y Jeon; Holly Alley; Bing Chen; Michael Goldberg; Steven Derrick; Sheldon Morris; William R Jacobs; Steven A Porcelli; Sunhee Lee
Journal:  PLoS One       Date:  2011-01-10       Impact factor: 3.240

10.  Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis.

Authors:  Michael Berney; Linda Berney-Meyer; Ka-Wing Wong; Bing Chen; Mei Chen; John Kim; Jingxin Wang; David Harris; Julian Parkhill; John Chan; Feng Wang; William R Jacobs
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-28       Impact factor: 11.205
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