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Literature DB >> 12819114

Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae.

Sharlene I Moore¹, Gary B Huffnagle, Gwo-Hsiao Chen, Eric S White, Peter Mancuso.

Abstract

Leptin is a pleiotropic hormone-cytokine known to regulate energy homeostasis and immune function. Neutrophils from leptin-deficient mice exhibited impaired phagocytosis of Klebsiella pneumoniae opsonized with serum containing complement and reduced CD11b expression that could be restored with exogenous leptin. These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12819114 PMCID： PMC161963 DOI： 10.1128/IAI.71.7.4182-4185.2003

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

1. Dietary restriction impairs neutrophil exudation by reducing CD11b/CD18 expression and chemokine production.

Authors: S Ikeda; H Saito; K Fukatsu; T Inoue; I Han; S Furukawa; T Matsuda; A Hidemura
Journal: Arch Surg Date: 2001-03

2. Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae.

Authors: P Mancuso; P Nana-Sinkam; M Peters-Golden
Journal: Infect Immun Date: 2001-04 Impact factor: 3.441

3. Reduced leptin levels in starvation increase susceptibility to endotoxic shock.

Authors: R Faggioni; A Moser; K R Feingold; C Grunfeld
Journal: Am J Pathol Date: 2000-05 Impact factor: 4.307

Review 4. Leptin.

Authors: R S Ahima; J S Flier
Journal: Annu Rev Physiol Date: 2000 Impact factor: 19.318

5. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice.

Authors: J K Howard; G M Lord; G Matarese; S Vendetti; M A Ghatei; M A Ritter; R I Lechler; S R Bloom
Journal: J Clin Invest Date: 1999-10 Impact factor: 14.808

6. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia.

Authors: Peter Mancuso; Andrew Gottschalk; Susan M Phare; Marc Peters-Golden; Nicholas W Lukacs; Gary B Huffnagle
Journal: J Immunol Date: 2002-04-15 Impact factor: 5.422

7. Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha.

Authors: A K Moshyedi; M D Josephs; E K Abdalla; S L Mackay; C K Edwards; E M Copeland; L L Moldawer
Journal: Infect Immun Date: 1998-04 Impact factor: 3.441

8. Leptin levels are associated with immune response in malnourished infants.

Authors: Ana Palacio; Marcelo Lopez; Francisco Perez-Bravo; Fernando Monkeberg; Liana Schlesinger
Journal: J Clin Endocrinol Metab Date: 2002-07 Impact factor: 5.958

9. Positional cloning of the mouse obese gene and its human homologue.

Authors: Y Zhang; R Proenca; M Maffei; M Barone; L Leopold; J M Friedman
Journal: Nature Date: 1994-12-01 Impact factor: 49.962

10. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?

Authors: F Caldefie-Chezet; A Poulin; A Tridon; B Sion; M P Vasson
Journal: J Leukoc Biol Date: 2001-03 Impact factor: 4.962

32 in total

Review 1. Adipocyte, adipose tissue, and infectious disease.

Authors: Mahalia S Desruisseaux; Maria E Trujillo; Herbert B Tanowitz; Philipp E Scherer
Journal: Infect Immun Date: 2006-11-21 Impact factor: 3.441

Review 2. Mouse Modeling of Obese Lung Disease. Insights and Caveats.

Authors: Benjamin T Suratt
Journal: Am J Respir Cell Mol Biol Date: 2016-08 Impact factor: 6.914

3. Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.

Authors: Jennifer M Dolan; Jason B Weinberg; Edmund O'Brien; Anya Abashian; Megan C Procario; David M Aronoff; Leslie J Crofford; Marc Peters-Golden; Lindsay Ward; Peter Mancuso
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2016-04-08 Impact factor: 5.464

Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae.

1. Dietary restriction impairs neutrophil exudation by reducing CD11b/CD18 expression and chemokine production.

2. Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae.

3. Reduced leptin levels in starvation increase susceptibility to endotoxic shock.

Review 4. Leptin.

5. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice.

6. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia.

7. Increased leptin expression in mice with bacterial peritonitis is partially regulated by tumor necrosis factor alpha.

8. Leptin levels are associated with immune response in malnourished infants.

9. Positional cloning of the mouse obese gene and its human homologue.

10. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?

Review 1. Adipocyte, adipose tissue, and infectious disease.

Review 2. Mouse Modeling of Obese Lung Disease. Insights and Caveats.

3. Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice.

4. Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats.

Review 5. Role of obesity and adipose tissue-derived cytokine leptin during Clostridium difficile infection.

Review 6. Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases.

Review 7. Obesity and nutrition in acute respiratory distress syndrome.

8. Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia.

Review 9. Role of leptin in the activation of immune cells.

10. Evidence of impairment of normal inflammatory reaction by a high-fat diet.