Literature DB >> 12815316

Immunosenescence and human longevity.

Graham Pawelec1.   

Abstract

Humans are almost certainly the longest-living of all mammals. What explains their longevity? Are there evolutionary pressures favouring longer life and if so what are they? If longevity is a positively selected trait, are many or few genes responsible for this characteristic? It is proposed here that human longevity was selected for at the level of relatively few genes and that many of these are involved in regulating the immune system.

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Year:  2003        PMID： 12815316     DOI： 10.1023/a:1024185405946

Source DB:  PubMed          Journal:  Biogerontology        ISSN： 1389-5729            Impact factor:   4.277


  4 in total

1.  Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae.

Authors:  Grace C Lee; Alvaro G Moreira; Cecilia Hinojosa; Raymond Benavides; Caitlyn Winter; Audrey C Anderson; Chang-Jui Chen; Noemi Borsa; Gabrielyd Hastings; Cody A Black; Sarah M Bandy; Alexander Shaffer; Marcos I Restrepo; Sunil K Ahuja
Journal:  Front Aging       Date:  2022-04-29

Review 2.  Aging, immunosenescence and membrane rafts: the lipid connection.

Authors:  Tamas Fulop; Aurélie Le Page; Hugo Garneau; Naheed Azimi; Sarra Baehl; Gilles Dupuis; Graham Pawelec; Anis Larbi
Journal:  Longev Healthspan       Date:  2012-10-04

Review 3.  Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity.

Authors:  Kira Rubtsova; Anatoly V Rubtsov; Michael P Cancro; Philippa Marrack
Journal:  J Immunol       Date:  2015-09-01       Impact factor: 5.422

Review 4.  Immunosupportive therapies in aging.

Authors:  Tamas Fülöp; Anis Larbi; Katsuiku Hirokawa; Eugenio Mocchegiani; Bruno Lesourds; Stephen Castle; Anders Wikby; Claudio Franceschi; Graham Pawelec
Journal:  Clin Interv Aging       Date:  2007       Impact factor: 4.458
  4 in total

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