Literature DB >> 12812483

Design and characterization of a homodimeric antiparallel coiled coil.

Daniel G Gurnon1, Jennifer A Whitaker, Martha G Oakley.   

Abstract

We report the first successful design of a self-associating antiparallel coiled coil, APH. The simultaneous application of Coulombic and hydrophobic components results in a decided preference for the antiparallel alignment as judged by HPLC, sedimentation equilibrium, and chemical denaturation data. The designed peptide is of comparable stability to naturally occurring leucine zipper peptides and can be expressed in bacteria. These properties of APH suggest potential in vivo protein fusion and biomaterials applications.

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Year:  2003        PMID： 12812483     DOI： 10.1021/ja0357590

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  24 in total

1.  High-resolution structures of a heterochiral coiled coil.

Authors:  David E Mortenson; Jay D Steinkruger; Dale F Kreitler; Dominic V Perroni; Gregory P Sorenson; Lijun Huang; Ritesh Mittal; Hyun Gi Yun; Benjamin R Travis; Mahesh K Mahanthappa; Katrina T Forest; Samuel H Gellman
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-12       Impact factor: 11.205

2.  Orientation and oligomerization specificity of the Bcr coiled-coil oligomerization domain.

Authors:  Christina M Taylor; Amy E Keating
Journal:  Biochemistry       Date:  2005-12-13       Impact factor: 3.162

3.  Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution.

Authors:  Maneesh K Yadav; Luke J Leman; Daniel J Price; Charles L Brooks; C David Stout; M Reza Ghadiri
Journal:  Biochemistry       Date:  2006-04-11       Impact factor: 3.162

4.  Competition between Coiled-Coil Structures and the Impact on Myosin-10 Bundle Selection.

Authors:  Kevin C Vavra; Youlin Xia; Ronald S Rock
Journal:  Biophys J       Date:  2016-06-07       Impact factor: 4.033

5.  Computational analysis of residue contributions to coiled-coil topology.

Authors:  Jorge Ramos; Themis Lazaridis
Journal:  Protein Sci       Date:  2011-09-20       Impact factor: 6.725

6.  Disruption of Bcr-Abl coiled coil oligomerization by design.

Authors:  Andrew S Dixon; Scott S Pendley; Benjamin J Bruno; David W Woessner; Adrian A Shimpi; Thomas E Cheatham; Carol S Lim
Journal:  J Biol Chem       Date:  2011-06-09       Impact factor: 5.157

7.  Influence of a heptad repeat stutter on the pH-dependent conformational behavior of the central coiled-coil from influenza hemagglutinin HA2.

Authors:  Chelsea D Higgins; Vladimir N Malashkevich; Steven C Almo; Jonathan R Lai
Journal:  Proteins       Date:  2014-05-06

Review 8.  Protein design: Past, present, and future.

Authors:  Lynne Regan; Diego Caballero; Michael R Hinrichsen; Alejandro Virrueta; Danielle M Williams; Corey S O'Hern
Journal:  Biopolymers       Date:  2015-07       Impact factor: 2.505

9.  A switch from parallel to antiparallel strand orientation in a coiled-coil X-ray structure via two core hydrophobic mutations.

Authors:  Vladimir N Malashkevich; Chelsea D Higgins; Steven C Almo; Jonathan R Lai
Journal:  Biopolymers       Date:  2015-05       Impact factor: 2.505

10.  Context-Dependent Stabilizing Interactions among Solvent-Exposed Residues along the Surface of a Trimeric Helix Bundle.

Authors:  Kimberlee L Stern; Mason S Smith; Wendy M Billings; Taylor J Loftus; Benjamin M Conover; Dennis Della Corte; Joshua L Price
Journal:  Biochemistry       Date:  2020-04-20       Impact factor: 3.162
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