PURPOSE: This study examined oocyte and embryo quality in patients having excessive ovarian responses during assisted reproduction treatment. METHODS: Two hundred and seventy-eight women of age <40 years using a long protocol of pituitary downregulation in their first intracytoplasmic sperm injection cycle indicated for severe male factors were retrospectively evaluated. Those with serum estradiol concentration on the day of HCG <10,000, 10,000-20,000, and >20,000 pmol/L were classified into Group A, Group B, and Group C, respectively. RESULTS: The percentage of metaphase II oocytes (85%), fertilization rate (60-66%), and distribution of blastomere number per embryo were similar among the three groups. The proportion of transferable embryos was not reduced in Group C when compared to those of Groups A and B. CONCLUSION: Excessive ovarian response does not compromise oocyte and embryo quality in humans. Freezing of all embryos is recommended in these patients in view of associated impaired endometrial receptivity.
PURPOSE: This study examined oocyte and embryo quality in patients having excessive ovarian responses during assisted reproduction treatment. METHODS: Two hundred and seventy-eight women of age <40 years using a long protocol of pituitary downregulation in their first intracytoplasmic sperm injection cycle indicated for severe male factors were retrospectively evaluated. Those with serum estradiol concentration on the day of HCG <10,000, 10,000-20,000, and >20,000 pmol/L were classified into Group A, Group B, and Group C, respectively. RESULTS: The percentage of metaphase II oocytes (85%), fertilization rate (60-66%), and distribution of blastomere number per embryo were similar among the three groups. The proportion of transferable embryos was not reduced in Group C when compared to those of Groups A and B. CONCLUSION: Excessive ovarian response does not compromise oocyte and embryo quality in humans. Freezing of all embryos is recommended in these patients in view of associated impaired endometrial receptivity.
Authors: Joseph E Peña; Peter L Chang; Lai-King Chan; Khaled Zeitoun; Melvin H Thornton; Mark V Sauer Journal: Hum Reprod Date: 2002-01 Impact factor: 6.918
Authors: A Pellicer; A Ruiz; R M Castellvi; C Calatayud; M Ruiz; J J Tarin; F Miró; F Bonilla-Musoles Journal: Hum Reprod Date: 1989-07 Impact factor: 6.918
Authors: Glykeria I Karatasiou; J K Bosdou; C A Venetis; L Zepiridis; K Chatzimeletiou; T B Tarlatzi; G Lainas; B C Tarlatzis; G Grimbizis; E M Kolibianakis Journal: J Assist Reprod Genet Date: 2020-05-29 Impact factor: 3.412