OBJECTIVE: To determine the incidence of overwork weakness in Charcot-Marie-Tooth disease (CMT). DESIGN: Prospective survey. SETTING: Rehabilitation department for CMT in an Italian tertiary care hospital. PARTICIPANTS: A total of 106 outpatients with CMT, selected for absence of other causes of weakness (age range, 11-69y), and 48 healthy volunteers (controls). INTERVENTIONS: The strength of 2 intrinsic hand muscles (abductor pollicis brevis [APB], first dorsal interosseous) in the dominant and nondominant hands was graded by using manual muscle testing and a modified Medical Research Council (MRC) Scale. MAIN OUTCOME MEASURES: The side of the stronger muscle and the difference in strength between the nondominant and dominant muscles. RESULTS: Muscles were stronger on the nondominant side in 65.57% of patients versus 1.04% of controls, and on the dominant side in .94% of patients versus 84.38% controls. The difference in strength for first dorsal interosseous was .51 in patients and -.32 in controls (P>.01). The difference in strength for APB was .65 in patients and -.35 in controls (P>.01). CONCLUSIONS: CMT muscles in the dominant hand are weaker than in the nondominant hand. This may be the result of overwork weakness.
OBJECTIVE: To determine the incidence of overwork weakness in Charcot-Marie-Tooth disease (CMT). DESIGN: Prospective survey. SETTING: Rehabilitation department for CMT in an Italian tertiary care hospital. PARTICIPANTS: A total of 106 outpatients with CMT, selected for absence of other causes of weakness (age range, 11-69y), and 48 healthy volunteers (controls). INTERVENTIONS: The strength of 2 intrinsic hand muscles (abductor pollicis brevis [APB], first dorsal interosseous) in the dominant and nondominant hands was graded by using manual muscle testing and a modified Medical Research Council (MRC) Scale. MAIN OUTCOME MEASURES: The side of the stronger muscle and the difference in strength between the nondominant and dominant muscles. RESULTS: Muscles were stronger on the nondominant side in 65.57% of patients versus 1.04% of controls, and on the dominant side in .94% of patients versus 84.38% controls. The difference in strength for first dorsal interosseous was .51 in patients and -.32 in controls (P>.01). The difference in strength for APB was .65 in patients and -.35 in controls (P>.01). CONCLUSIONS:CMT muscles in the dominant hand are weaker than in the nondominant hand. This may be the result of overwork weakness.
Authors: Sergio Tejero; Juan Chans-Veres; Andrés Carranza-Bencano; Ahmed E Galhoum; Daniel Poggio; Victor Valderrábano; Mario Herrera-Pérez Journal: Int Orthop Date: 2021-02-21 Impact factor: 3.075
Authors: P J Arthur-Farraj; S M Murphy; M Laura; M P Lunn; H Manji; J Blake; G Ramdharry; Z Fox; M M Reilly Journal: Neuromuscul Disord Date: 2012-03-28 Impact factor: 4.296
Authors: L Mori; A Signori; V Prada; D Pareyson; G Piscosquito; L Padua; C Pazzaglia; G M Fabrizi; A Picelli; A Schenone Journal: Eur J Neurol Date: 2019-09-25 Impact factor: 6.089