| Literature DB >> 12808258 |
Souichi Kawamoto1, Takashi Koyano, Thaworn Kowithayakorn, Haruhiro Fujimoto, Emi Okuyama, Masahiko Hayashi, Kanki Komiyama, Masami Ishibashi.
Abstract
Two new pregnane alkaloids, wrightiamines A (1) and B (2), were isolated from the extract of the tropical Apocynaceous plant Wrightia javanica collected in Thailand, and their structures were elucidated by spectral data. Wrightiamine B (2) was preparaed from 3beta-hydroxy-5alpha-pregnan-20-one to establish the configuration of the C-20 position as S. Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.Entities:
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Year: 2003 PMID： 12808258 DOI： 10.1248/cpb.51.737
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645