Literature DB >> 12807801

False discovery rate in linkage and association genome screens for complex disorders.

Chiara Sabatti1, Susan Service, Nelson Freimer.   

Abstract

We explore the implications of the false discovery rate (FDR) controlling procedure in disease gene mapping. With the aid of simulations, we show how, under models commonly used, the simple step-down procedure introduced by Benjamini and Hochberg controls the FDR for the dependent tests on which linkage and association genome screens are based. This adaptive multiple comparison procedure may offer an important tool for mapping susceptibility genes for complex diseases.

Mesh：

Year:  2003        PMID： 12807801      PMCID： PMC1462572     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  8 in total

1.  Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations.

Authors:  S K Service; D W Lang; N B Freimer; L A Sandkuijl
Journal:  Am J Hum Genet       Date:  1999-06       Impact factor: 11.025

2.  Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate.

Authors:  Roel A Ophoff; Michael A Escamilla; Susan K Service; Mitzi Spesny; Dar B Meshi; Wingman Poon; Julio Molina; Eduardo Fournier; Alvaro Gallegos; Carol Mathews; Thomas Neylan; Steven L Batki; Erin Roche; Margarita Ramirez; Sandra Silva; Melissa C De Mille; Penny Dong; Pedro E Leon; Victor I Reus; Lodewijk A Sandkuijl; Nelson B Freimer
Journal:  Am J Hum Genet       Date:  2002-07-15       Impact factor: 11.025

3.  A new approach to the problem of multiple comparisons in the genetic dissection of complex traits.

Authors:  J I Weller; J Z Song; D W Heyen; H A Lewin; M Ron
Journal:  Genetics       Date:  1998-12       Impact factor: 4.562

4.  Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

Authors:  E S Lander; D Botstein
Journal:  Genetics       Date:  1989-01       Impact factor: 4.562

5.  Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.

Authors:  E Lander; L Kruglyak
Journal:  Nat Genet       Date:  1995-11       Impact factor: 38.330

6.  Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent.

Authors:  J Dupuis; P O Brown; D Siegmund
Journal:  Genetics       Date:  1995-06       Impact factor: 4.562

7.  Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent.

Authors:  E Feingold; P O Brown; D Siegmund
Journal:  Am J Hum Genet       Date:  1993-07       Impact factor: 11.025

8.  Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms.

Authors:  E S Lander; D Botstein
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205
  8 in total
  58 in total

1.  Cost-effective designs for linkage disequilibrium mapping of complex traits.

Authors:  Susan K Service; Lodewijk A Sandkuijl; Nelson B Freimer
Journal:  Am J Hum Genet       Date:  2003-04-14       Impact factor: 11.025

2.  Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies.

Authors:  Frank Dudbridge; Bobby P C Koeleman
Journal:  Am J Hum Genet       Date:  2004-07-19       Impact factor: 11.025

3.  Statistical tests for admixture mapping with case-control and cases-only data.

Authors:  Giovanni Montana; Jonathan K Pritchard
Journal:  Am J Hum Genet       Date:  2004-09-22       Impact factor: 11.025

4.  Assessing the probability that a positive report is false: an approach for molecular epidemiology studies.

Authors:  Sholom Wacholder; Stephen Chanock; Montserrat Garcia-Closas; Laure El Ghormli; Nathaniel Rothman
Journal:  J Natl Cancer Inst       Date:  2004-03-17       Impact factor: 13.506

5.  Molecular Genetics and Economics.

Authors:  Jonathan P Beauchamp; David Cesarini; Magnus Johannesson; Matthijs J H M van der Loos; Philipp D Koellinger; Patrick J F Groenen; James H Fowler; J Niels Rosenquist; A Roy Thurik; Nicholas A Christakis
Journal:  J Econ Perspect       Date:  2011

6.  Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia.

Authors:  Beng-Choon Ho; Thomas H Wassink; Steven Ziebell; Nancy C Andreasen
Journal:  Schizophr Res       Date:  2011-03-21       Impact factor: 4.939

7.  Coalescent-based association mapping and fine mapping of complex trait loci.

Authors:  Sebastian Zöllner; Jonathan K Pritchard
Journal:  Genetics       Date:  2004-10-16       Impact factor: 4.562

8.  On the sample size requirement in genetic association tests when the proportion of false positives is controlled.

Authors:  Guohua Zou; Yijun Zuo
Journal:  Genetics       Date:  2005-10-03       Impact factor: 4.562

9.  Altered upper airway and soft tissue structures in the New Zealand Obese mouse.

Authors:  Michael J Brennick; Allan I Pack; Kei Ko; Eugene Kim; Stephen Pickup; Greg Maislin; Richard J Schwab
Journal:  Am J Respir Crit Care Med       Date:  2008-11-07       Impact factor: 21.405

Review 10.  Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

Authors:  George R Uhl; Tomas Drgon; Catherine Johnson; Chuan-Yun Li; Carlo Contoreggi; Judith Hess; Daniel Naiman; Qing-Rong Liu
Journal:  Ann N Y Acad Sci       Date:  2008-10       Impact factor: 5.691
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