Literature DB >> 12804182

Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation.

Natalja Fehse1, Boris Fehse, Nicolaus Kröger, Tatjana Zabelina, Petra Freiberger, William Krüger, Hartmut Kabisch, Rudolf Erttmann, Axel R Zander.   

Abstract

The aim of this work was to analyze the influence of anti-thymocyte globulin (ATG) as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation. The rate and pattern of the recovery of total lymphocytes, natural killer (NK) cells, and several T and B cell subsets were determined in 38 patients for more than 2 years following BMT. We compared two patient groups: the first comprised 19 patients after matched related BMT without ATG prevention for graft-versus-host disease (GVHD) and the second contained 19 patients after matched related BMT with ATG treatment for GVHD prophylaxis. We observed impaired immune reconstitution in the ATG group in comparison with the non-ATG group, indicating a significant influence of ATG on immune recovery for several months after BMT.

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Year:  2003        PMID： 12804182     DOI： 10.1089/152581603321628377

Source DB:  PubMed          Journal:  J Hematother Stem Cell Res        ISSN： 1525-8165


  17 in total

1.  Monocyte-mediated T-cell suppression and augmented monocyte tryptophan catabolism after human hematopoietic stem-cell transplantation.

Authors:  Ursula Hainz; Petra Obexer; Christiana Winkler; Peter Sedlmayr; Osamu Takikawa; Hildegard Greinix; Anita Lawitschka; Ulrike Pötschger; Dietmar Fuchs; Stephan Ladisch; Andreas Heitger
Journal:  Blood       Date:  2005-01-27       Impact factor: 22.113

2.  Effective prevention of GVHD using in vivo T-cell depletion with anti-lymphocyte globulin in HLA-identical or -mismatched sibling peripheral blood stem cell transplantation.

Authors:  C Wolschke; T Zabelina; F Ayuk; H Alchalby; J Berger; E Klyuchnikov; U-M Pein; S Schumacher; G Amtsfeld; R Adjallé; F Wortmann; H Lellek; A Randenborgh; A Zander; N Kröger
Journal:  Bone Marrow Transplant       Date:  2013-09-16       Impact factor: 5.483

3.  Impact of low-dose anti-thymocyte globulin on immune reconstitution after allogeneic hematopoietic cell transplantation.

Authors:  Ayumu Ito; Shigehisa Kitano; Kinuko Tajima; Youngji Kim; Takashi Tanaka; Yoshihiro Inamoto; Sung-Won Kim; Noboru Yamamoto; Takahiro Fukuda; Shinichiro Okamoto
Journal:  Int J Hematol       Date:  2019-10-22       Impact factor: 2.490

4.  Hand grip strength and 2-minute walk test in chronic graft-versus-host disease assessment: analysis from the Chronic GVHD Consortium.

Authors:  Joseph Pidala; Xiaoyu Chai; Paul Martin; Yoshihiro Inamoto; Corey Cutler; Jeanne Palmer; Daniel Weisdorf; Steven Pavletic; Mukta Arora; Madan Jagasia; David Jacobsohn; Stephanie J Lee
Journal:  Biol Blood Marrow Transplant       Date:  2013-03-27       Impact factor: 5.742

5.  Late-onset hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation in patients with advanced leukemia: differences in ATG dosage are key.

Authors:  Haixia Fu; Lanping Xu; Daihong Liu; Xiaohui Zhang; Kaiyan Liu; Huan Chen; Yu Wang; Wei Han; Tingting Han; Xiaojun Huang
Journal:  Int J Hematol       Date:  2013-04-30       Impact factor: 2.490

6.  Immune recovery after allogeneic hematopoietic stem cell transplantation: is it time to revisit how patients are monitored?

Authors:  Miguel-Angel Perales; Marcel R M van den Brink
Journal:  Biol Blood Marrow Transplant       Date:  2012-09-27       Impact factor: 5.742

7.  ATG in allogeneic stem cell transplantation: standard of care in 2017? Counterpoint.

Authors:  Natasha Kekre; Joseph H Antin
Journal:  Blood Adv       Date:  2017-03-28

8.  Lower dose anti-thymocyte globulin for GvHD prophylaxis results in improved survival after allogeneic stem cell transplantation.

Authors:  L Binkert; M Medinger; J P Halter; D Heim; S Gerull; A Holbro; C Lengerke; M Weisser; J R Passweg
Journal:  Bone Marrow Transplant       Date:  2015-06-29       Impact factor: 5.483

9.  Comparison of different rabbit ATG preparation effects on early lymphocyte subset recovery after allogeneic HSCT and its association with EBV-mediated PTLD.

Authors:  Angela Mensen; Il-Kang Na; Ralf Häfer; Astrid Meerbach; Maria Schlecht; Marie-Luise Pietschmann; Bernd Gruhn
Journal:  J Cancer Res Clin Oncol       Date:  2014-06-25       Impact factor: 4.553

10.  Immune reconstitution after anti-thymocyte globulin-conditioned hematopoietic cell transplantation.

Authors:  Mark Bosch; Manveer Dhadda; Mette Hoegh-Petersen; Yiping Liu; Laura M Hagel; Peter Podgorny; Alejandra Ugarte-Torres; Faisal M Khan; Joanne Luider; Iwona Auer-Grzesiak; Adnan Mansoor; James A Russell; Andrew Daly; Douglas A Stewart; David Maloney; Michael Boeckh; Jan Storek
Journal:  Cytotherapy       Date:  2012-09-18       Impact factor: 5.414
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