| Literature DB >> 1280333 |
A V Hill1, J Elvin, A C Willis, M Aidoo, C E Allsopp, F M Gotch, X M Gao, M Takiguchi, B M Greenwood, A R Townsend.
Abstract
The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide from liver-stage-specific antigen-1 (LSA-1), but no HLA-B53-restricted epitopes were identified in other antigens. These findings indicate a possible molecular basis for this HLA-disease association and support the candidacy of liver-stage-specific antigen-1 as a malaria vaccine component.Entities:
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Year: 1992 PMID： 1280333 DOI： 10.1038/360434a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962